Applications and evolution of melittin, the quintessential membrane active peptide
Melittin, the main venom component of the European Honeybee, is a cationic linear peptide-
amide of 26 amino acid residues with the sequence: GIGAVLKVLTTGLPALISWIKRKRQQ …
amide of 26 amino acid residues with the sequence: GIGAVLKVLTTGLPALISWIKRKRQQ …
Mechanistic landscape of membrane-permeabilizing peptides
Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …
[HTML][HTML] Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect
F Dabbagh Moghaddam, I Akbarzadeh… - Cancer …, 2021 - Springer
Background Melittin, a peptide component of honey bee venom, is an appealing candidate
for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty …
for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty …
Resonance energy transfer: methods and applications
PG Wu, L Brand - Analytical biochemistry, 1994 - Elsevier
Resonance energy transfer is widely used in studies of biomolecular structure and
dynamics. It provides information about distances on the order of 10 to 100 Å and is thus …
dynamics. It provides information about distances on the order of 10 to 100 Å and is thus …
[HTML][HTML] Barrel-stave model or toroidal model? A case study on melittin pores
Transmembrane pores induced by amphiphilic peptides, including melittin, are often
modeled with the barrel-stave model after the alamethicin pore. We examine this …
modeled with the barrel-stave model after the alamethicin pore. We examine this …
Bee venom in cancer therapy
N Oršolić - Cancer and metastasis reviews, 2012 - Springer
Abstract Bee venom (BV)(api-toxin) has been widely used in the treatment of some immune-
related diseases, as well as in recent times in treatment of tumors. Several cancer cells …
related diseases, as well as in recent times in treatment of tumors. Several cancer cells …
Melittin: a membrane-active peptide with diverse functions
H Raghuraman, A Chattopadhyay - Bioscience reports, 2007 - portlandpress.com
Melittin is the principal toxic component in the venom of the European honey bee Apis
mellifera and is a cationic, hemolytic peptide. It is a small linear peptide composed of 26 …
mellifera and is a cationic, hemolytic peptide. It is a small linear peptide composed of 26 …
[HTML][HTML] Toroidal pores formed by antimicrobial peptides show significant disorder
A large variety of antimicrobial peptides have been shown to act, at least in vitro, by poration
of the lipid membrane. The nanometre size of these pores, however, complicates their …
of the lipid membrane. The nanometre size of these pores, however, complicates their …
The actions of melittin on membranes
CE Dempsey - Biochimica et Biophysica Acta (BBA)-Reviews on …, 1990 - Elsevier
The molecular mechanisms underlying the various effects of melittin on membranes have
not been completely defined and much of the evidence described indicates that different …
not been completely defined and much of the evidence described indicates that different …
Host defense peptides as new weapons in cancer treatment
N Papo, Y Shai - Cellular and Molecular Life Sciences CMLS, 2005 - Springer
In the last decade intensive research has been conducted to determine the role of innate
immunity host defense peptides (also termed antimicrobial peptides) in the killing of …
immunity host defense peptides (also termed antimicrobial peptides) in the killing of …