Overcoming the blood–brain barrier. challenges and tricks for CNS drug delivery

LA Bors, F Erdő - Scientia Pharmaceutica, 2019 - mdpi.com
Treatment of certain central nervous system disorders, including different types of cerebral
malignancies, is limited by traditional oral or systemic administrations of therapeutic drugs …

Sustained drug release from smart nanoparticles in cancer therapy: a comprehensive review

X Bai, ZL Smith, Y Wang, S Butterworth, A Tirella - Micromachines, 2022 - mdpi.com
Although nanomedicine has been highly investigated for cancer treatment over the past
decades, only a few nanomedicines are currently approved and in the market; making this …

Hazard assessment of polymeric nanobiomaterials for drug delivery: what can we learn from literature so far

S Jesus, M Schmutz, C Som, G Borchard… - … in bioengineering and …, 2019 - frontiersin.org
The physicochemical properties of nanobiomaterials, such as their small size and high
surface area ratio, make them attractive, novel drug-carriers, with increased cellular …

Effect of Paclitaxel/etoposide co-loaded polymeric nanoparticles on tumor size and survival rate in a rat model of glioblastoma

H Maleki, MRH Najafabadi, TJ Webster… - International journal of …, 2021 - Elsevier
The aim of this work is to co-load paclitaxel (PTX) and etoposide (ETP) in methoxy poly
(ethylene glycol)-poly (lactic-co-glycolic acid) nanoparticles (mPEG-PLGA NPs) to overcome …

Magnetic core-shell hybrid nanoparticles for receptor targeted anti-cancer therapy and magnetic resonance imaging

A Shanavas, S Sasidharan, D Bahadur… - Journal of Colloid and …, 2017 - Elsevier
Hybrid nanoparticles with magnetic poly (lactide-co-glycolide)(PLGA) nanoparticle 'core',
surface modified with folate-chitosan (fol-cht) conjugate 'shell'are evaluated as simultaneous …

Functionalized PLGA nanoparticles prepared by nano-emulsion templating interact selectively with proteins involved in the transport through the blood-brain barrier

M Monge, C Fornaguera, C Quero, A Dols-Perez… - European Journal of …, 2020 - Elsevier
During the last few decades, extensive efforts has been made to design nanocarriers to
transport drugs into the central nervous system (CNS). However, its efficacy is limited due to …

Rosmarinic acid-loaded polymeric nanoparticles prepared by low-energy nano-emulsion templating: Formulation, biophysical characterization, and in vitro studies

J García-Melero, JJ López-Mitjavila, MJ García-Celma… - Materials, 2022 - mdpi.com
Rosmarinic acid (RA), a caffeic acid derivative, has been loaded in polymeric nanoparticles
made up of poly (lactic-co-glycolic acid)(PLGA) through a nano-emulsion templating process …

Design of novel proliposome formulation for antioxidant peptide, glutathione with enhanced oral bioavailability and stability

JC Byeon, SE Lee, TH Kim, JB Ahn, DH Kim… - Drug …, 2019 - Taylor & Francis
To develop proliposome formulations to improve the oral bioavailability of l-glutathione
(GSH), GSH-loaded proliposomes were prepared using the granule method. Mannitol was …

[HTML][HTML] Charge-Reversal Nano-Drug Delivery Systems in the Tumor Microenvironment: Mechanisms, Challenges, and Therapeutic Applications

Y Liang, J Wu, Y Yan, Y Wang, H Zhao, X Wang… - International Journal of …, 2024 - mdpi.com
The charge-reversal nano-drug delivery system (CRNDDS) is a promising system for
delivering chemotherapy drugs and has gained widespread application in cancer treatment …

Transferrin-conjugated doxorubicin-loaded PLGA nanoparticles with pH-responsive behavior: a synergistic approach for cancer therapy

LE Scheeren, DR Nogueira-Librelotto… - Journal of Nanoparticle …, 2020 - Springer
Doxorubicin (DOX) is an efficient chemotherapeutic agent widely used to treat different types
of cancer; however, there is an inherent risk of adverse effects due to its unspecific action in …