Several unexpected reports of iron–sulphur clusters in nucleic acid binding proteins have
recently appeared in the literature. Once thought to be relatively rare in these systems, iron …

Guanine rich nucleic acid sequences can form G-quadruplex (G4) structures that interfere
with DNA replication, repair and RNA transcription. The human FANCJ helicase contributes …

XPD-like helicases constitute a prominent DNA helicase family critical for many aspects of
genome maintenance. These enzymes share a unique structural feature, an auxiliary …

New boron carriers with high boron content and targeted cancer-cell delivery are considered
the first choice for boron neutron capture therapy (BNCT) for cancer treatment. Previously …

We report a dual illumination, single-molecule imaging strategy to dissect directly and in real-
time the correlation between nanometer-scale domain motion of a DNA repair protein and its …

Effective transcription, replication, and maintenance of the genome require a diverse set of
molecular machines to perform the many chemical transactions that constitute these …

Molecular machines within cells dynamically assemble, disassemble and reorganize.
Molecular interactions between their components can be observed at the single-molecule …

The metazoan mitochondrial DNA helicase is an integral part of the minimal mitochondrial
replisome. It exhibits strong sequence homology with the bacteriophage T7 gene 4 protein …

Escherichia coli YoaA aids in the resolution of DNA damage that halts DNA synthesis in vivo
in conjunction with χ, an accessory subunit of DNA polymerase III. YoaA and χ form a …

Understanding how cells regulate and transport metal ions is an important goal in the field of
bioinorganic chemistry, a frontier research area that resides at the interface of chemistry and …