CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …

CD44, a non-kinase transmembrane glycoprotein, is overexpressed in several cell types
including cancer stem cells and frequently shows alternative spliced variants that are …

Pancreatic cancers with aberrant expression of macrophage migration inhibitory factor (MIF)
are particularly aggressive. To identify key signaling pathways that drive disease …

Although changes in alternative splicing have been observed in cancer, their functional
contributions still remain largely unclear. Here we report that splice isoforms of the cancer …

CD44, a multi-structural and multifunctional transmembrane glycoprotein, was initially
identified as a receptor for hyaluronan that participates in both physiological and …

Abstract GRP78 (glucose-regulated protein, 78 kDa) is a key regulator of endoplasmic
reticulum (ER) stress signaling. Cancer cells are highly proliferative and have high demand …

Metastasis is the leading cause of cancer death, tumor progression proceeding through
emigration from the primary tumor, gaining access to the circulation, leaving the circulation …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy that harbors
mutations in homologous recombination–repair (HR-repair) proteins in 20%–25% of cases …

The tripartite-motif (TRIM) family represents one of the largest classes of putative single
protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular …

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It
has a poor response to conventional therapy and has an extremely poor 5-year survival rate …