Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing
an indispensable role in neuronal development and memory formation. The dysregulation of …

The kainic acid model of temporal lobe epilepsy has greatly contributed to the
understanding of the molecular, cellular and pharmacological mechanisms underlying …

Abstract N-methyl-d-aspartate (NMDA) receptors are Hebbian-like coincidence detectors,
requiring binding of glycine and glutamate in combination with the relief of voltage …

The initial reports regarding a cytotoxic role of calcium ions were published over 30 years
ago. In neurons, calcium ions can gain entry into the cell through several mechanisms …

The N-methyl D-aspartate (NMDA) receptor subtype of glutamate-gated ion channels
possesses high calcium permeability and unique voltage-dependent sensitivity to …

The glutamate receptors mediate excitatory neurotransmission in the brain and are
important in memory acquisition, learning, and some neurodegenerative disorders. This …

Excitatory neurotransmission mediated by NMDA (N-methyl-d-aspartate) receptors is
fundamental to the physiology of the mammalian central nervous system. These receptors …

A complementary DNA encoding the rat NMDA receptor has been cloned and characterized.
The single protein encoded by the cDNA forms a receptor-channel complex that has …

Glutamate receptors (GluRs) mediate most of the excitatory neurotransmission in the
mammalian central nervous system (CNS). In addition, they are involved in plastic changes …