The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …

Enhancers control the establishment of spatiotemporal gene expression patterns throughout
development. Over the past decade, the development of new technologies has improved our …

Regulatory landscapes drive complex developmental gene expression, but it remains
unclear how their integrity is maintained when incorporating novel genes and functions …

Comprehensive enhancer discovery is challenging because most enhancers, especially
those contributing to complex diseases, have weak effects on gene expression. Our gene …

Recent deep learning models that predict the Hi-C contact map from DNA sequence achieve
promising accuracy but cannot generalize to new cell types and or even capture differences …

Coxiella burnetii is a bacterial pathogen that replicates within host cells by establishing a
membrane-bound niche called the Coxiella-containing vacuole. Biogenesis of this …

In recent years, the exploration of genome three-dimensional (3D) conformation has yielded
profound insights into the regulation of gene expression and cellular functions in both …

Using an adult female miniature pig model with diet-induced weight gain/weight loss, we
investigated the regulatory mechanisms of three-dimensional (3D) genome architecture in …

Abstract Background Topologically associating domains (TADs) are thought to act as
functional units in the genome. TADs co-localise genes and their regulatory elements as …

The specificity of gene expression during development requires the insulation of regulatory
domains to avoid inappropriate enhancer-gene interactions. In vertebrates, this insulator …