A spinal cord injury disrupts communication between the brain and the circuits in the spinal
cord that regulate neurological functions. The consequences are permanent paralysis, loss …

Highlights•Modulation of synaptic strength can occur through changes in short-term
plasticity.•Modulators can shape or induce long-term synaptic plasticity.•Modulators can …

Spinal cord injury (SCI) interrupts long-projecting descending spinal neurons and disrupts
the spinal central pattern generator (CPG) that controls locomotion. The intrinsic …

It is now accepted that neurons contain and release multiple transmitter substances.
However, we still have only limited insight into the regulation and functional effects of this co …

Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We
assessed the necessity of myelin regulatory factor (Myrf) in remyelination after contusive SCI …

Serotonin (5-HT), a monoamine neurotransmitter synthesized in various populations of
brainstem neurons, plays an important role in modulating the activity of spinal networks …

Locomotion is a complex motor task executed by spinal neurons. Given the diversity of
spinal cord neurons, linking neuronal cell type to function is a challenge. Molecular …

Body-weight supported locomotor training (BWST) promotes recovery of load-bearing
stepping in lower mammals, but its efficacy in individuals with a spinal cord injury (SCI) is …

Abstract The 5-HT 2C receptor (R) displays a widespread distribution in the CNS and is
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …

Muscle spasms are common in chronic spinal cord injury (SCI), posing challenges to
rehabilitation and daily activities. Pharmacological management of spasms mostly targets …