Targeted protein degradation can provide advantages over inhibition approaches in the
development of therapeutic strategies. Lysosome-targeting chimeras (LYTACs) harness …

Data independent acquisition mass spectrometry (DIA-MS) has recently emerged as an
important method for the identification of blood-based biomarkers. However, the large …

Accurate biomarkers are a crucial and necessary precondition for precision medicine, yet
existing ones are often unspecific and new ones have been very slow to enter the clinic …

Phosphoproteomics and ubiquitinomics data-independent acquisition (DIA) mass
spectrometry (MS) data is typically analyzed by using a data-dependent acquisition (DDA) …

Mass spectrometry-based proteomics has been rapidly gaining traction as a powerful
analytical method both in basic research and translation. While the problem of error control …

The fidelity of signal transduction requires the binding of regulatory molecules to their
cognate targets. However, the crowded cell interior risks off-target interactions between …

Although data-independent acquisition (DIA) has the ability to identify and quantify all
peptides in a sample, highly complex mixed mass spectra present difficulties for accurate …

Abstract The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium
(CPTAC) provides unique opportunities for cancer target discovery using protein expression …

Heterogeneity is an inherent quality of biological systems, and is one of the properties that
facilitates adaptation of organisms to new environments and stimuli. However, the scientific …