Genome or gene editing includes several new techniques to help scientists precisely modify
genome sequences. The techniques also enables us to alter the regulation of gene …

JF Gudernatsch, an anatomist at Cornell Medical School, traveled by ship to the Naples
Zoological Station in the summer of 1910. He took along various mammalian organs …

A major obstacle to creating precisely expressed transgenes lies in the epigenetic effects of
the host chromatin that surrounds them. Here we present a strategy to overcome this …

Xenopus laevis is the model of choice for evolutionary, comparative, and developmental
studies of immunity, and invaluable research tools including MHC‐defined clones, inbred …

The site-specific integrase from bacteriophage ϕC31 functions in mammalian cells and is
being applied for genetic engineering, including gene therapy. The ϕC31 integrase …

The use of recombinases for genomic engineering is no longer a new technology. In fact,
this technology has entered its third decade since the initial discovery that recombinases …

The identification and characterization of the regulatory activity of genomic sequences is
crucial for understanding how the information contained in genomes is translated into …

The C31 integrase system represents a novel technology that opens up new possibilities
for gene therapy. The C31 integrase can integrate introduced plasmid DNA into preferred …

Most temperate phages encode an integrase for integration and excision of the prophage.
Integrases belong either to the λ Int family of tyrosine recombinases or to a subgroup of the …

We describe a microinjection-based φC31 integrase mRNA-mediated method for creating
transgenic Drosophila strains. This approach is more efficient than traditional methods and …