The incidence of chronic pain is high in the general population and it is closely related to
anxiety disorders, which promote negative effects on the quality of life. The cannabinoid …

Key points The central nucleus of the amygdala (CeA) encompasses the main output
pathways of the amygdala, a temporal lobe structure essential in affective and cognitive …

This paper is the fortieth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

The amygdala is a key subcortical region believed to contribute to emotional components of
pain. As opioid receptors are found in both the central (CeA) and basolateral (BLA) nuclei of …

Dysfunction of glutamatergic synaptic plasticity in basolateral amygdala (BLA) constitutes a
critical pathogenic mechanism underlying the depression-like behaviors induced by chronic …

Background The amygdala plays a key role in fear learning and extinction and has emerged
as an important node of emotional-affective aspects of pain and pain modulation. Impaired …

The amygdala plays an important role in the emotional-affective aspects of behaviors and
pain, but can also modulate sensory aspect of pain (“nociception”), likely through coupling to …

Inter-individual and sex differences in pain responses are recognized but their mechanisms
are not well understood. This study was intended to provide the behavioral framework for …

Despite being closely related, bonobos and chimpanzees exhibit several behavioral
differences. For instance, studies indicate that chimpanzees are more aggressive, territorial …

Paclitaxel is widely used as a first-line chemotherapy agent to treat malignant tumors.
However, paclitaxel causes peripheral nerve fiber damage and neuropathic pain in some …