Chronic pain in HIV
The evolution of therapeutics for and management of human immunodeficiency virus-1 (HIV-
1) infection has shifted it from predominately manifesting as a severe, acute disease with …
1) infection has shifted it from predominately manifesting as a severe, acute disease with …
Opioid and neuroHIV comorbidity–current and future perspectives
With the current national opioid crisis, it is critical to examine the mechanisms underlying
pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in …
pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in …
Increased pain sensitivity and decreased opioid analgesia in T-cell-deficient mice and implications for sex differences
The processing of pain in the central nervous system is now known to have an important
immune component, including T cells of the adaptive immune system. T cells have been …
immune component, including T cells of the adaptive immune system. T cells have been …
CCR5 mediates HIV-1 Tat-induced neuroinflammation and influences morphine tolerance, dependence, and reward
M Gonek, VD McLane, DL Stevens, K Lippold… - Brain, behavior, and …, 2018 - Elsevier
The HIV-1 regulatory protein, trans-activator of transcription (Tat), interacts with opioids to
potentiate neuroinflammation and neurodegeneration within the CNS. These effects may …
potentiate neuroinflammation and neurodegeneration within the CNS. These effects may …
Selective vulnerability of striatal D2 versus D1 dopamine receptor-expressing medium spiny neurons in HIV-1 Tat transgenic male mice
Despite marked regional differences in HIV susceptibility within the CNS, there has been
surprisingly little exploration into the differential vulnerability among neuron types and the …
surprisingly little exploration into the differential vulnerability among neuron types and the …
Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein
HIV-associated sensory neuropathies (HIV-SN) are prevalent in> 50% of patients aged over
45 years many of which report moderate to severe chronic pain. Previous preclinical studies …
45 years many of which report moderate to severe chronic pain. Previous preclinical studies …
Accelerated brain aging with opioid misuse and HIV: New insights on the role of glially derived pro-inflammation mediators and neuronal chloride homeostasis
KF Hauser, M Ohene-Nyako, PE Knapp - Current opinion in neurobiology, 2023 - Elsevier
Opioid use disorder (OUD) has become a national crisis and contributes to the spread of
human immunodeficiency virus (HIV) infection. Emerging evidence and advances in …
human immunodeficiency virus (HIV) infection. Emerging evidence and advances in …
Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice
BJ Yadav-Samudrala, BL Gorman… - Frontiers in …, 2024 - frontiersin.org
Background Some evidence suggests that cannabidiol (CBD) has potential to help alleviate
HIV symptoms due to its antioxidant and anti-inflammatory properties. Here we examined …
HIV symptoms due to its antioxidant and anti-inflammatory properties. Here we examined …
Endogenous opiates and behavior: 2013
RJ Bodnar - Peptides, 2014 - Elsevier
This paper is the thirty-sixth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2013 …
concerning the endogenous opioid system. It summarizes papers published during 2013 …
Independent actions by HIV-1 Tat and morphine to increase recruitment of monocyte-derived macrophages into the brain in a region-specific manner
CR Leibrand, JJ Paris, AM Jones, M Ohene-Nyako… - Neuroscience …, 2022 - Elsevier
Despite advances in the treatment of human immunodeficiency virus (HIV), approximately
one-half of people infected with HIV (PWH) experience neurocognitive impairment. Opioid …
one-half of people infected with HIV (PWH) experience neurocognitive impairment. Opioid …