Intratumor heterogeneity has been widely reported in human cancers, but our knowledge of
how this genetic diversity emerges over time remains limited. A central challenge in studying …

Metastatic tumors are the cause of more than 90% of cancer related deaths. Metastasis
formation can be considered as a culmination of the Darwinian evolutionary process within …

Metastases are responsible for the majority of cancer-related deaths. Although genomic
heterogeneity within primary tumors is associated with relapse, heterogeneity among …

Genetic intratumoural heterogeneity is a natural consequence of imperfect DNA replication.
Any two randomly selected cells, whether normal or cancerous, are therefore genetically …

Polyploidy is observed across the tree of life, yet its influence on evolution remains
incompletely understood,,,. Polyploidy, usually whole-genome duplication, is proposed to …

Cancer is a somatic evolutionary process characterized by the accumulation of mutations,
which contribute to tumor growth, clinical progression, immune escape, and drug resistance …

Abstract Treatment of advanced cancers has benefited from new agents that supplement or
bypass conventional therapies. However, even effective therapies fail as cancer cells deploy …

Intratumor heterogeneity represents a major obstacle to effective cancer treatment and
personalized medicine. However, investigators are now elucidating intratumor heterogeneity …

Heterogeneity is a hallmark of tumors and has a crucial role in the outcome of the
malignancy, because it not only confounds diagnosis, but also challenges the design of …

Purpose To examine heterogeneous breast cancer through intravoxel incoherent motion
(IVIM) histogram analysis. Materials and methods This HIPAA-compliant, IRB-approved …