After anaphase onset, animal cells build an actomyosin contractile ring that constricts the
plasma membrane to generate two daughter cells connected by a cytoplasmic bridge. The …

For decades after the discovery that a contractile ring made of actin filaments and myosin II
produces the force to constrict the cleavage furrow of animal cells, the complexity of …

Exit from mitosis in budding yeast requires a group of essential proteins—including the
GTPase Tem1 and the protein phosphatase Cdc14—that downregulate cyclin-dependent …

The genus Trichoderma contains fungi with high relevance for humans, with applications in
enzyme production for plant cell wall degradation and use in biocontrol. Here, we provide a …

Cytokinesis is a temporally and spatially regulated process through which the cellular
constituents of the mother cell are partitioned into two daughter cells, permitting an increase …

When the first mutant allele of the Drosophila gene polo was first characterized over 10
years ago, attention focused on the defects that centrosome behavior exhibited at various …

A conserved signalling cascade—termed the mitotic-exit network in budding yeast and the
septation-initiation network in fission yeast—controls key events during exit from mitosis and …

Exit from mitosis must not occur prior to partitioning of chromosomes between daughter
cells. We find that the GTP binding protein Tem1, a regulator of mitotic exit, is present on the …

Bfa1p and Bub2p are spindle checkpoint proteins that likely have GTPase activation activity
and are associated with the budding yeast spindle pole body (SPB). Here, we show that …

Centrosomes—as well as the related spindle pole bodies (SPBs) of yeast—have been
extensively studied from the perspective of their microtubule-organizing roles. Moreover, the …