Vesicular monoamine transporters (VMAT) are responsible for the uptake of cytosolic
monoamines into synaptic vesicles in monoaminergic neurons. Two closely related VMATs …

The majority of pharmaceuticals and other organic compounds incorporating radiotracers
that are considered foreign to the body undergo metabolic changes in vivo. Metabolic …

The ability to noninvasively measure endogenous pancreatic β-cell mass (BCM) would
accelerate research on the pathophysiology of diabetes and revolutionize the preclinical …

Diabetes mellitus (DM) has emerged into a steadily increasing health problem and the
predicted future dimension of the global DM epidemic is alarming: an increase from currently …

Type 2 vesicular monoamine transporter (VMAT2), found in the brain, is also expressed by β-
cells of the pancreas in association with insulin. Preclinical experiments suggested that 11C …

Glucagon-like peptide 1 receptor (GLP-1R) is highly expressed in pancreatic islets,
especially on β-cells. Therefore, a properly labeled ligand that binds to GLP-1R could be …

Recent studies on gene expression of β-cell mass (BCM) in the pancreas showed that
vesicular monoamine transporter 2 (VMAT2) is highly expressed in the BCM (mainly in the …

Since diabetes is becoming a global epidemic, there is a great need to develop early β-cell
specific diagnostic techniques for this disorder. There are two types of diabetes (ie, type 1 …

Abstract Vesicular monoamine transporter 2 (VMAT2) is expressed in pancreatic beta cells
and has recently been proposed as a target for measurement of beta cell mass in vivo. We …

Cell replacement therapy for diabetes mellitus requires cost-effective generation of high-
quality, insulin-producing, pancreatic β cells from pluripotent stem cells. Development of this …