Subretinal drusenoid deposits AKA pseudodrusen

RF Spaide, S Ooto, CA Curcio - Survey of ophthalmology, 2018 - Elsevier
A distinction between conventional drusen and pseudodrusen was first made in 1990, and
more recently knowledge of pseudodrusen, more accurately called subretinal drusenoid …

Perspective on AMD pathobiology: a bioenergetic crisis in the RPE

CR Fisher, DA Ferrington - Investigative ophthalmology & …, 2018 - iovs.arvojournals.org
AMD is the leading cause of blindness in developed countries. The dry form of AMD, also
known as atrophic AMD, is characterized by the death of RPE and photoreceptors. Currently …

[HTML][HTML] The clinical relevance of visualising the peripheral retina

N Quinn, L Csincsik, E Flynn, CA Curcio, S Kiss… - Progress in retinal and …, 2019 - Elsevier
Recent developments in imaging technologies now allow the documentation, qualitative and
quantitative evaluation of peripheral retinal lesions. As wide field retinal imaging, capturing …

Ultra-widefield retinal imaging: an update on recent advances

SN Patel, A Shi, TD Wibbelsman… - Therapeutic advances …, 2020 - journals.sagepub.com
The development of ultra-widefield retinal imaging has accelerated our understanding of
common retinal diseases. As we continue to validate the diagnostic and prognostic …

Age-related macular degeneration: epidemiology and clinical aspects

TDL Keenan, CA Cukras, EY Chew - … : From Clinic to Genes and Back to …, 2021 - Springer
Age-related macular degeneration (AMD) is a degenerative disease of the human retina
affecting individuals over the age of 55 years. This heterogeneous condition arises from a …

On the origin of proteins in human drusen: The meet, greet and stick hypothesis

AA Bergen, S Arya, C Koster, MG Pilgrim… - Progress in Retinal and …, 2019 - Elsevier
Retinal drusen formation is not only a clinical hallmark for the development of age-related
macular degeneration (AMD) but also for other disorders, such as Alzheimer's disease and …

Ultra-wide field retinal imaging: A wider clinical perspective

V Kumar, A Surve, D Kumawat, B Takkar… - Indian Journal of …, 2021 - journals.lww.com
The peripheral retina is affected in a variety of retinal disorders. Traditional fundus cameras
capture only a part of the fundus even when montaging techniques are used. Ultra-wide field …

Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration

JZ Chuang, N Yang, N Nakajima, W Otsu, C Fu… - Nature …, 2022 - nature.com
Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly. Dry AMD has unclear etiology and no treatment. Lipid-rich drusen are the hallmark …

Quantifying retinal pigment epithelium dysmorphia and loss of histologic autofluorescence in age-related macular degeneration

JA Gambril, KR Sloan, TA Swain… - … & visual science, 2019 - iovs.arvojournals.org
Purpose: Lipofuscin and melanolipofuscin organelles in retinal pigment epithelium (RPE)
cells are signal sources for clinical fundus autofluorescence (AF). To elucidate the …

Cuticular drusen: clinical phenotypes and natural history defined using multimodal imaging

C Balaratnasingam, S Cherepanoff, R Dolz-Marco… - Ophthalmology, 2018 - Elsevier
Purpose To define the range and life cycles of cuticular drusen phenotypes using
multimodal imaging and to review the histologic characteristics of cuticular drusen. Design …