The renin-angiotensin system (RAS) is recognized as a key element in blood pressure
regulation and electrolyte/fluid homeostasis. 1 As outlined in Figure 1, the RAS constitutes a …

Protein and lipid oxidation—mainly by mitochondrial reactive oxygen species (mtROS)—
was proposed as a crucial determinant of health and lifespan. Angiotensin II (Ang II) …

В книге рассмотрены современные патогенные, патофизиологические, клинические,
инструментальные и терапевтические аспекты атеросклеротического повреждения …

Background—Little is known about the pathophysiology of myxomatous degeneration of the
mitral valve, the pathological hallmark of mitral valve prolapse, associated with symptomatic …

This multicentre study compared the antihypertensive effect and tolerability of the novel
angiotensin II antagonist candesartan cilexetil with those of losartan and placebo. Men and …

It has been known since the 1990s that long-term morbidity and mortality is improved in
patients with heart failure with reduced ejection fraction (HFrEF) by treatments that target the …

Objective: This study compares the antihypertensive efficacy and tolerability of valsartan, a
novel angiotensin II antagonist, given with hydrochlorothiazide (HCTZ) vs placebo or vs …

Abstract According to the World Health Organization predictions cardiovascular diseases
will be the leading cause of death by the year 2020. High blood pressure is a major risk …

Candesartan cilexetil is rapidly and completely hydrolysed to the active compound
candesartan during absorption from the gastrointestinal tract. Candesartan is a potent, long …

With ongoing improvements in cancer therapy and health care, the population of long-term
cancer survivors continues to grow: 62% of adult and 77% of pediatric cancer patients …