A novel BH3 mimetic Bcl-2 inhibitor promotes autophagic cell death and reduces in vivo Glioblastoma tumor growth
Anti-apoptotic members of the Bcl-2 family proteins play central roles in the regulation of cell
death in glioblastoma (GBM), the most malignant type of brain tumor. Despite the advances …
death in glioblastoma (GBM), the most malignant type of brain tumor. Despite the advances …
Design, Synthesis, and Biological Evaluation of Newly Synthesized Cinnamide-Fluorinated Containing Compounds as Bioactive Anticancer Agents
D Nasser Binjawhar, FA Al-Salmi, MA Alghamdi… - ACS …, 2024 - ACS Publications
A new series of cinnamide-fluorinated derivatives has been synthesized and characterized
by using different spectroscopic and elemental microanalyses methods. All of the prepared p …
by using different spectroscopic and elemental microanalyses methods. All of the prepared p …
Synthesis and evaluation of some new imidazolone bearing phthalyl and tosyl amino acids moities as anti-cancer agents supported by molecular docking
A facile and convenient synthesis of imidazolone-incorporated phthalyl and/or p-tosyl amino
acid derivatives was described. The reaction of oxazolone derivative 2 with p …
acid derivatives was described. The reaction of oxazolone derivative 2 with p …
Lisinopril Can Reduce Genotoxicity of L-Asparaginase in Bone Marrow Stem Cells
MI Maleek - Open Access Macedonian Journal of Medical Sciences, 2022 - oamjms.eu
BACKGROUND: Lisinopril is a medication used to lower blood pressure by inhibiting the
angiotensin-converting enzyme (ACE). L-asparaginase is a chemotherapeutic agent used to …
angiotensin-converting enzyme (ACE). L-asparaginase is a chemotherapeutic agent used to …
[PDF][PDF] ISTANBUL TECHNICAL UNIVERSITY★ GRADUATE SCHOOL
Ş ÇALIŞ - 2022 - polen.itu.edu.tr
Purpose of the thesis was to test and explore mechanism of action of computationally
designated novel Bcl-2 inhibitor small molecules that have potential to treat glial tumors. We …
designated novel Bcl-2 inhibitor small molecules that have potential to treat glial tumors. We …