Inflammation and tumor progression: signaling pathways and targeted intervention
H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …
either promotes or suppresses tumor progression, potentially displaying opposing effects on …
Mucosal immune responses to infection and vaccination in the respiratory tract
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
A conserved dendritic-cell regulatory program limits antitumour immunity
Checkpoint blockade therapies have improved cancer treatment, but such immunotherapy
regimens fail in a large subset of patients. Conventional type 1 dendritic cells (DC1s) control …
regimens fail in a large subset of patients. Conventional type 1 dendritic cells (DC1s) control …
PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer
Inhibiting the programmed death-1 (PD-1) pathway is one of the most effective approaches
to cancer immunotherapy, but its mechanistic basis remains incompletely understood …
to cancer immunotherapy, but its mechanistic basis remains incompletely understood …
[HTML][HTML] NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control
Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity, and their
abundance within tumors is associated with immune-mediated rejection and the success of …
abundance within tumors is associated with immune-mediated rejection and the success of …
Dendritic cells revisited
M Cabeza-Cabrerizo, A Cardoso… - Annual review of …, 2021 - annualreviews.org
Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …
Properties and functions of adipose tissue macrophages in obesity
The expansion of adipose tissue (AT) in obesity is accompanied by the accumulation of
immune cells that contribute to a state of low‐grade, chronic inflammation and dysregulated …
immune cells that contribute to a state of low‐grade, chronic inflammation and dysregulated …
Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses
KL Hilligan, F Ronchese - Cellular & molecular immunology, 2020 - nature.com
Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …
Expansion and activation of CD103+ dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition
H Salmon, J Idoyaga, A Rahman, M Leboeuf… - Immunity, 2016 - cell.com
Large numbers of melanoma lesions develop resistance to targeted inhibition of mutant
BRAF or fail to respond to checkpoint blockade. We explored whether modulation of …
BRAF or fail to respond to checkpoint blockade. We explored whether modulation of …
[HTML][HTML] The cis-regulatory atlas of the mouse immune system
A complete chart of cis-regulatory elements and their dynamic activity is necessary to
understand the transcriptional basis of differentiation and function of an organ system. We …
understand the transcriptional basis of differentiation and function of an organ system. We …