The involvement of inflammasomes in the proinflammatory response observed in chronic
liver diseases, such as alcohol-associated liver disease (ALD) and nonalcoholic fatty liver …

Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …

Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular events
in humans with type 2 diabetes (T2D); however, the underlying mechanism remains unclear …

Abstract Angiotensin-converting enzyme 2 (ACE2) has proven beneficial in attenuating
diabetic cardiomyopathy (DCM) but has been found to be a substrate of a disintegrin and …

Autophagy is a self-eating catabolic pathway that contributes to liver homeostasis through its
role in energy balance and in the quality control of the cytoplasm, by removing misfolded …

Obesity poses a severe threat to human health, including the increased prevalence of
hypertension, insulin resistance, diabetes mellitus, cancer, inflammation, sleep apnoea and …

Inflammasome is a complex of multiple proteins found in cytoplasm of the cells activated by
infectious and/or non-infectious stimuli. This complex involves caspase-1 activation, leading …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Inflammasomes are multiprotein complexes that can sense danger signals and activate
caspase-1 to mediate pro-inflammatory cytokines release and pyroptotic cell death. There …