The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

Calorie restriction (CR) promotes healthy ageing in diverse species. Recently, it has been
shown that fasting for a portion of each day has metabolic benefits and promotes lifespan …

Nutrition profoundly influences the risk for many age‐related diseases. Whether nutrition
influences human aging biology directly is less clear. Studies in different animal species …

The evolutionary context of why caloric restriction (CR) activates physiological mechanisms
that slow the process of aging remains unclear. The main goal of this analysis was to …

Aging is strongly related to energy metabolism, but the underlying processes and
mechanisms are complex and incompletely understood. Restricting energy intake and …

Metabolic diseases, such as diabetes and non-alcoholic fatty liver disease (NAFLD), have
several negative health outcomes on affected humans. Dysregulated energy metabolism is …

Adipose tissue plays an essential role in metabolic health. Ames dwarf mice are
exceptionally long-lived and display metabolically beneficial phenotypes in their adipose …

Calorie restriction (CR) and exercise training (EX) are two critical lifestyle interventions for
the prevention and treatment of metabolic diseases, such as obesity and diabetes. Brown …

Cardiometabolic diseases present an escalating global health and economic burden. Such
a surge is driven by epidemic prevalence rates of metabolic disorders, such as obesity and …

Caloric restriction (CR) is the leading non-pharmaceutical dietary intervention to improve
health-and lifespan in most model organisms. A wide array of cellular pathways is induced …