The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

Abstract Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …

Squamous cell lung cancers (lung squamous cell carcinomas [LUSCs]) are associated with
high mortality and a lack of therapies specific to this disease. Although recurrent molecular …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

Epigenetic modifiers frequently harbor loss-of-function mutations in lung cancer, but their
tumor-suppressive roles are poorly characterized. Histone methyltransferase KMT2D (a …

Lung squamous cell carcinoma (LUSC) represents a major subtype of lung cancer with
limited treatment options. KMT2D is one of the most frequently mutated genes in LUSC (> …

Cancer genome sequencing consortiums have recently catalogued an abundance of
somatic mutations, across a wide range of human cancers, in the chromatin-modifying …

Inhibiting glycolysis remains an aspirational approach for the treatment of cancer. We have
previously identified a subset of cancers harbouring homozygous deletion of the glycolytic …

Epigenetic mechanisms are central to understanding the molecular basis underlying
tumorigenesis. Aberrations in epigenetic modifiers alter epigenomic landscapes and play a …