With the advent of technologies to obtain the complete sequence of the human genome in a
cost-effective manner, this decade and those to come will see an exponential increase in our …

Several classes of biological molecules that transform chemical energy into mechanical
work are known as motor proteins or molecular motors. These nanometer-sized machines …

The combinatorial nature of many important mathematical problems, including
nondeterministic-polynomial-time (NP)-complete problems, places a severe limitation on the …

We hypothesize that age-related skeletal muscle dysfunction and physical disability may be
partially explained by alterations in the function of the myosin molecule. To test this …

Computer simulations can aid in understanding how collective materials properties emerge
from interactions between simple constituents. Here, we introduce a coarse-grained model …

Mutations at a highly conserved homologous residue in three closely related muscle
myosins cause three distinct diseases involving muscle defects: R671C in β-cardiac myosin …

Molecular motors such as kinesin and myosin often work in groups to generate the directed
movements and forces critical for many biological processes. Although much is known about …

Skeletal muscle contractile function declines with aging, disease, and disuse. In vivo muscle
contractile function depends on a variety of factors, but force, contractile velocity and power …

In this paper we report, clarify and broaden various recent efforts to complement the
chemistry-centered models of force generation in (skeletal) muscles by mechanics-centered …

Abstract Concepts in molecular tension sensing in biology are growing and have their
origins in studies of muscle contraction. In the heart muscle, a key parameter of contractility …