Sensory fibers of the peripheral nervous system carry sensation from specific sense
structures or use different tissues and organs as receptive fields, and convey this information …

This review covers recent advances in understanding the molecular mechanisms controlling
neurogenesis and specification of the developing retina, with a focus on insights obtained …

Cone cells constitute only 3% of the photoreceptors of the wild-type (WT) mouse. While
mouse rods have been thoroughly investigated with suction pipette recordings of their outer …

Background Inherited retinal disorders are clinically and genetically heterogeneous with
more than 150 gene defects accounting for the diversity of disease phenotypes. So far …

Approximately 98% of mammalian DNA is noncoding, yet we understand relatively little
about the function of this enigmatic portion of the genome. The cis-regulatory elements that …

OBJECTIVE NEUROD1 is expressed in both developing and mature β-cells. Studies in mice
suggest that this basic helix-loop-helix transcription factor is critical in the development of …

During vertebrate retinogenesis, seven classes of cells are specified from multipotent
progenitors. To date, the mechanisms underlying multipotent cell fate determination by …

Rod and cone photoreceptors in the mammalian retina are special types of neurons that are
responsible for phototransduction, the first step of vision. Development and maintenance of …

We targeted 266 CAG repeats (a number that causes infantile-onset disease) into the mouse
Sca7 locus to generate an authentic model of spinocerebellar ataxia type 7 (SCA7). These …

Proneural basic helix–loop–helix proteins are key regulators of neurogenesis but their
'proneural'function is not well understood, partly because primary targets have not been …