Repurposing degradation pathways for modular metabolite biosynthesis in nematodes

CJJ Wrobel, FC Schroeder - Nature chemical biology, 2023 - nature.com
Recent studies have revealed that Caenorhabditis elegans and other nematodes repurpose
products from biochemical degradation pathways for the combinatorial assembly of complex …

Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans

BW Fox, MJ Helf, RN Burkhardt, AB Artyukhin… - Nature …, 2024 - nature.com
Fatty acid desaturation is central to metazoan lipid metabolism and provides building blocks
of membrane lipids and precursors of diverse signaling molecules. Nutritional conditions …

Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles

HH Le, CJJ Wrobel, SM Cohen, J Yu, H Park, MJ Helf… - Elife, 2020 - elifesciences.org
Signaling molecules derived from attachment of diverse metabolic building blocks to
ascarosides play a central role in the life history of C. elegans and other nematodes; …

Convergent evolution of small molecule pheromones in Pristionchus nematodes

C Dong, CJ Weadick, V Truffault, RJ Sommer - Elife, 2020 - elifesciences.org
The small molecules that mediate chemical communication between nematodes—so-called
'nematode-derived-modular-metabolites'(NDMMs)—are of major interest because of their …

[HTML][HTML] Evolutionarily related host and microbial pathways regulate fat desaturation

BW Fox, MJ Helf, RN Burkhardt, AB Artyukhin, BJ Curtis… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Fatty acid desaturation is central to metazoan lipid metabolism and provides building blocks
of membrane lipids and precursors of diverse signaling molecules. Nutritional conditions …

Dimerization of conserved ascaroside building blocks generates species-specific male attractants in Caenorhabditis nematodes

C Dong, F Dolke, S Bandi, C Paetz… - Organic & biomolecular …, 2020 - pubs.rsc.org
Comparative ascaroside profiling of Caenorhabditis nematodes using HPLC-ESI-(−)-MS/MS
precursor ion scanning revealed a class of highly species-specific ascaroside dimers. Their …

[PDF][PDF] Modular metabolite assembly in C. elegans lysosome-related organelles

HH Le, CJJ Wrobel, SM Cohen, J Yu… - BioRxiv, in press …, 2020 - authors.library.caltech.edu
Abstract 1 Signaling molecules derived from attachment of diverse primary metabolic
building blocks to 2 ascarosides play a central role in the life history of C. elegans and other …

[图书][B] Formation and Function of Ascarosides in the Nematodes C. elegans and C. briggsae

SM Cohen - 2021 - search.proquest.com
As an easily culturable, hermaphroditic, and short-lived species with a fully annotated
genome and neural connectome, the nematode Caenorhabditis elegansis used as a model …

[PDF][PDF] Modular metabolite assembly in

HH Le, CJJ Wrobel, SM Cohen, J Yu, H Park, MJ Helf… - academia.edu
Signaling molecules derived from attachment of diverse metabolic building blocks to
ascarosides play a central role in the life history of C. elegans and other nematodes; …

[PDF][PDF] タンデム反応を基盤としたexiguolide の全合成

飯尾慶, イイオケイ - 2020 - chuo-u.repo.nii.ac.jp
イグジグオリド (1, Figure 1) は奄美大島沿岸で採取した希少な海綿 Geodia exigua から,
太田らにより単離・構造決定されたマクロリドである 1. 本天然物はヒト非小細胞肺がん細胞に対し …