Imaging advances in chronic obstructive pulmonary disease. Insights from the genetic epidemiology of chronic obstructive pulmonary disease (COPDGene) study
SP Bhatt, GR Washko, EA Hoffman… - American journal of …, 2019 - atsjournals.org
The Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study,
which began in 2007, is an ongoing multicenter observational cohort study of more than …
which began in 2007, is an ongoing multicenter observational cohort study of more than …
Influence of acellular natural lung matrix on murine embryonic stem cell differentiation and tissue formation
J Cortiella, J Niles, A Cantu, A Brettler… - … Engineering Part A, 2010 - liebertpub.com
We report here the first attempt to produce and use whole acellular (AC) lung as a matrix to
support development of engineered lung tissue from murine embryonic stem cells (mESCs) …
support development of engineered lung tissue from murine embryonic stem cells (mESCs) …
Recent advances and new opportunities in lung mechanobiology
DJ Tschumperlin, F Boudreault, F Liu - Journal of biomechanics, 2010 - Elsevier
Lung function is inextricably linked to mechanics. On short timescales every breath
generates dynamic cycles of cell and matrix stretch, along with convection of fluids in the …
generates dynamic cycles of cell and matrix stretch, along with convection of fluids in the …
Mechanics of a fiber network within a non-fibrillar matrix: model and comparison with collagen-agarose co-gels
While collagen is recognized as the predominant mechanical component of soft connective
tissues, the role of the non-fibrillar matrix (NFM) is less well understood. Even model …
tissues, the role of the non-fibrillar matrix (NFM) is less well understood. Even model …
Computed tomography measure of lung at risk and lung function decline in chronic obstructive pulmonary disease
Rationale: The rate of decline of lung function is greater than age-related change in a
substantial proportion of patients with chronic obstructive pulmonary disease, even after …
substantial proportion of patients with chronic obstructive pulmonary disease, even after …
Multiscale model predicts tissue-level failure from collagen fiber-level damage
MF Hadi, EA Sander, VH Barocas - 2012 - asmedigitalcollection.asme.org
Excessive tissue-level forces communicated to the microstructure and extracellular matrix of
soft tissues can lead to damage and failure through poorly understood physical processes …
soft tissues can lead to damage and failure through poorly understood physical processes …
Epithelial and endothelial damage induced by mechanical ventilation modes
Epithelial and endothelial damage induced by mechanical vent... : Current Opinion in Critical
Care Epithelial and endothelial damage induced by mechanical ventilation modes : Current …
Care Epithelial and endothelial damage induced by mechanical ventilation modes : Current …
An analytical model for estimating alveolar wall elastic moduli from lung tissue uniaxial stress-strain curves
S Bou Jawde, A Takahashi, JHT Bates… - Frontiers in physiology, 2020 - frontiersin.org
The non-linear stress-strain behavior of uniaxially-stretched lung parenchyma is thought to
be an emergent phenomenon arising from the ensemble behavior of its microscopic …
be an emergent phenomenon arising from the ensemble behavior of its microscopic …
Fiber networks below the isostatic point: Fracture without stress concentration
Crack nucleation, in which a crack is propagated via the concentration of stress at its tip, is a
ubiquitous phenomenon. Here, we show via simulations and theory that in systems such as …
ubiquitous phenomenon. Here, we show via simulations and theory that in systems such as …
Micropatterned cell sheets with defined cell and extracellular matrix orientation exhibit anisotropic mechanical properties
BC Isenberg, DE Backman, ME Kinahan… - Journal of …, 2012 - Elsevier
For an arterial replacement graft to be effective, it must possess the appropriate strength in
order to withstand long-term hemodynamic stress without failure, yet be compliant enough …
order to withstand long-term hemodynamic stress without failure, yet be compliant enough …