Mechanisms of 3D cell migration

KM Yamada, M Sixt - Nature Reviews molecular cell biology, 2019 - nature.com
Cell migration is essential for physiological processes as diverse as development, immune
defence and wound healing. It is also a hallmark of cancer malignancy. Thousands of …

Harnessing the potential of hydrogels for advanced therapeutic applications: Current achievements and future directions

P Lu, D Ruan, M Huang, M Tian, K Zhu… - … and Targeted Therapy, 2024 - nature.com
The applications of hydrogels have expanded significantly due to their versatile, highly
tunable properties and breakthroughs in biomaterial technologies. In this review, we cover …

The front and rear of collective cell migration

R Mayor, S Etienne-Manneville - Nature reviews Molecular cell biology, 2016 - nature.com
Collective cell migration has a key role during morphogenesis and during wound healing
and tissue renewal in the adult, and it is involved in cancer spreading. In addition to …

Physical influences of the extracellular environment on cell migration

G Charras, E Sahai - Nature reviews Molecular cell biology, 2014 - nature.com
The way in which a cell migrates is influenced by the physical properties of its surroundings,
in particular the properties of the extracellular matrix. How the physical aspects of the cell's …

[HTML][HTML] Cancer invasion and the microenvironment: plasticity and reciprocity

P Friedl, S Alexander - Cell, 2011 - cell.com
Cancer invasion is a cell-and tissue-driven process for which the physical, cellular, and
molecular determinants adapt and react throughout the progression of the disease. Cancer …

Cortical contractility triggers a stochastic switch to fast amoeboid cell motility

V Ruprecht, S Wieser, A Callan-Jones, M Smutny… - Cell, 2015 - cell.com
Summary 3D amoeboid cell migration is central to many developmental and disease-related
processes such as cancer metastasis. Here, we identify a unique prototypic amoeboid cell …

Focal adhesion–independent cell migration

EK Paluch, IM Aspalter, M Sixt - Annual review of cell and …, 2016 - annualreviews.org
Cell migration is central to a multitude of physiological processes, including embryonic
development, immune surveillance, and wound healing, and deregulated migration is key to …

Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration

D Cai, SC Chen, M Prasad, L He, X Wang… - Cell, 2014 - cell.com
E-cadherin is a major homophilic cell-cell adhesion molecule that inhibits motility of
individual cells on matrix. However, its contribution to migration of cells through cell-rich …

Life at the leading edge

AJ Ridley - Cell, 2011 - cell.com
Cell migration requires sustained forward movement of the plasma membrane at the cell's
front or" leading edge." To date, researchers have uncovered four distinct ways of extending …

Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo

Y Li, X Du, C Liu, Z Wen, J Du - Developmental cell, 2012 - cell.com
Microglia are the primary immune cells in the brain. Under physiological conditions, they
typically stay in a" resting" state, with ramified processes continuously extending to and …