1, 2, 4-Triazolo [1, 5-a] pyrimidines in drug design
K Oukoloff, B Lucero, KR Francisco, KR Brunden… - European journal of …, 2019 - Elsevier
Abstract The 1, 2, 4-triazolo [1, 5-a] pyrimidine (TP) heterocycle, in spite of its relatively
simple structure, has proved to be remarkably versatile as evidenced by its use in many …
simple structure, has proved to be remarkably versatile as evidenced by its use in many …
Synthesis, structure elucidation, antioxidant, antimicrobial, anti-inflammatory and molecular docking studies of transition metal (II) complexes derived from heterocyclic …
In the search of significant biological agents for the pathogenic causing deformities, four
bidentate heterocyclic Schiff base ligands and their sixteen Co (II), Ni (II), Cu (II) and Zn (II) …
bidentate heterocyclic Schiff base ligands and their sixteen Co (II), Ni (II), Cu (II) and Zn (II) …
Biological activities of [1,2,4]triazolo[1,5-a]pyrimidines and analogs
S Pinheiro, EMC Pinheiro, EMF Muri… - Medicinal Chemistry …, 2020 - Springer
Abstract The [1, 2, 4] triazolo [1, 5-a] pyrimidines (TPs) comprise an important class of non-
naturally occurring small molecules that aroused the interest of researches. This scaffold is …
naturally occurring small molecules that aroused the interest of researches. This scaffold is …
Recent advances in 1, 2, 4-triazolo [1, 5-a] pyrimidine chemistry
G Fischer - Advances in Heterocyclic Chemistry, 2019 - Elsevier
The review deals with the pharmaceutically and agrochemically important group of 1, 2, 4-
triazolo [1, 5-a] pyrimidines (TPs) and covers relevant literature published from about 2006 …
triazolo [1, 5-a] pyrimidines (TPs) and covers relevant literature published from about 2006 …
First-Row Transition 7-Oxo-5-phenyl-1, 2, 4-triazolo [1, 5-a] pyrimidine Metal Complexes: Antiparasitic Activity and Release Studies
Á Martín-Montes, S Jimenez-Falcao, S Gómez-Ruiz… - Pharmaceuticals, 2023 - mdpi.com
Leishmaniasis and Chagas disease are still considered neglected illnesses due to the lack
of investment in research, despite the fact that almost one million new cases are reported …
of investment in research, despite the fact that almost one million new cases are reported …
Cytotoxic activity of organotin (IV) derivatives with triazolopyrimidine containing exocyclic oxygen atoms
A Attanzio, S D'Agostino, R Busà, A Frazzitta, S Rubino… - Molecules, 2020 - mdpi.com
In this study cytotoxicity of organotin (IV) compounds with 1, 2, 4-triazolo [1, 5-a] pyrimidines,
Me3Sn (5tpO)(1), n-Bu3Sn (5tpO)(2), Me3Sn (mtpO)(3), n-Bu3Sn (mtpO)(4), n-Bu3Sn …
Me3Sn (5tpO)(1), n-Bu3Sn (5tpO)(2), Me3Sn (mtpO)(3), n-Bu3Sn (mtpO)(4), n-Bu3Sn …
In vitro leishmanicidal and trypanocidal evaluation and magnetic properties of 7-amino-1, 2, 4-triazolo [1, 5-a] pyrimidine Cu (II) complexes
Two triazolopyrimidine complexes have been obtained from reaction between 7-amino-1, 2,
4-triazolo [1, 5-a] pyrimidine (7atp) and Cu (II) salts. Crystal structures of [Cu 2 (μ-7atp) 4 Cl …
4-triazolo [1, 5-a] pyrimidine (7atp) and Cu (II) salts. Crystal structures of [Cu 2 (μ-7atp) 4 Cl …
[HTML][HTML] Recent Advances in Metal Complexes Based on Biomimetic and Biocompatible Organic Ligands against Leishmaniasis Infections: State of the Art and …
S Jimenez-Falcao, JM Mendez-Arriaga - Inorganics, 2024 - mdpi.com
Leishmaniasis is a complex disease present in a variety of manifestations listed by the World
Health Organization (WHO) as one of the neglected diseases with a worse prognosis if not …
Health Organization (WHO) as one of the neglected diseases with a worse prognosis if not …
[HTML][HTML] In vitro anti-Trypanosoma cruzi activity of ternary copper (II) complexes and in vivo evaluation of the most promising complex
DA Paixão, CD Lopes, ZA Carneiro, LM Sousa… - Biomedicine & …, 2019 - Elsevier
In order to improve the previously observed antichagasic activity of Cu (II) complexes
containing 2-chlorobenzhydrazide (2-CH), we report herein the synthesis and anti …
containing 2-chlorobenzhydrazide (2-CH), we report herein the synthesis and anti …
Recent Trends in the Chemistry of [1, 2, 4] Triazole [1, 5-a] pyrimidines
AM Mohamed, WA El-Sayed, AA Ibrahim… - Organic Preparations …, 2021 - Taylor & Francis
1, 2, 4-Triazole moieties have been incorporated into a wide variety of therapeutically
interesting drug candidates including central nervous system stimulants, sedatives …
interesting drug candidates including central nervous system stimulants, sedatives …