1, 2, 4-Triazolo [1, 5-a] pyrimidines in drug design

K Oukoloff, B Lucero, KR Francisco, KR Brunden… - European journal of …, 2019 - Elsevier
Abstract The 1, 2, 4-triazolo [1, 5-a] pyrimidine (TP) heterocycle, in spite of its relatively
simple structure, has proved to be remarkably versatile as evidenced by its use in many …

Synthesis, structure elucidation, antioxidant, antimicrobial, anti-inflammatory and molecular docking studies of transition metal (II) complexes derived from heterocyclic …

B Kumar, J Devi, A Manuja - Research on Chemical Intermediates, 2023 - Springer
In the search of significant biological agents for the pathogenic causing deformities, four
bidentate heterocyclic Schiff base ligands and their sixteen Co (II), Ni (II), Cu (II) and Zn (II) …

Biological activities of [1,2,4]triazolo[1,5-a]pyrimidines and analogs

S Pinheiro, EMC Pinheiro, EMF Muri… - Medicinal Chemistry …, 2020 - Springer
Abstract The [1, 2, 4] triazolo [1, 5-a] pyrimidines (TPs) comprise an important class of non-
naturally occurring small molecules that aroused the interest of researches. This scaffold is …

Recent advances in 1, 2, 4-triazolo [1, 5-a] pyrimidine chemistry

G Fischer - Advances in Heterocyclic Chemistry, 2019 - Elsevier
The review deals with the pharmaceutically and agrochemically important group of 1, 2, 4-
triazolo [1, 5-a] pyrimidines (TPs) and covers relevant literature published from about 2006 …

First-Row Transition 7-Oxo-5-phenyl-1, 2, 4-triazolo [1, 5-a] pyrimidine Metal Complexes: Antiparasitic Activity and Release Studies

Á Martín-Montes, S Jimenez-Falcao, S Gómez-Ruiz… - Pharmaceuticals, 2023 - mdpi.com
Leishmaniasis and Chagas disease are still considered neglected illnesses due to the lack
of investment in research, despite the fact that almost one million new cases are reported …

Cytotoxic activity of organotin (IV) derivatives with triazolopyrimidine containing exocyclic oxygen atoms

A Attanzio, S D'Agostino, R Busà, A Frazzitta, S Rubino… - Molecules, 2020 - mdpi.com
In this study cytotoxicity of organotin (IV) compounds with 1, 2, 4-triazolo [1, 5-a] pyrimidines,
Me3Sn (5tpO)(1), n-Bu3Sn (5tpO)(2), Me3Sn (mtpO)(3), n-Bu3Sn (mtpO)(4), n-Bu3Sn …

In vitro leishmanicidal and trypanocidal evaluation and magnetic properties of 7-amino-1, 2, 4-triazolo [1, 5-a] pyrimidine Cu (II) complexes

JM Méndez-Arriaga, I Oyarzabal, G Escolano… - Journal of inorganic …, 2018 - Elsevier
Two triazolopyrimidine complexes have been obtained from reaction between 7-amino-1, 2,
4-triazolo [1, 5-a] pyrimidine (7atp) and Cu (II) salts. Crystal structures of [Cu 2 (μ-7atp) 4 Cl …

[HTML][HTML] Recent Advances in Metal Complexes Based on Biomimetic and Biocompatible Organic Ligands against Leishmaniasis Infections: State of the Art and …

S Jimenez-Falcao, JM Mendez-Arriaga - Inorganics, 2024 - mdpi.com
Leishmaniasis is a complex disease present in a variety of manifestations listed by the World
Health Organization (WHO) as one of the neglected diseases with a worse prognosis if not …

[HTML][HTML] In vitro anti-Trypanosoma cruzi activity of ternary copper (II) complexes and in vivo evaluation of the most promising complex

DA Paixão, CD Lopes, ZA Carneiro, LM Sousa… - Biomedicine & …, 2019 - Elsevier
In order to improve the previously observed antichagasic activity of Cu (II) complexes
containing 2-chlorobenzhydrazide (2-CH), we report herein the synthesis and anti …

Recent Trends in the Chemistry of [1, 2, 4] Triazole [1, 5-a] pyrimidines

AM Mohamed, WA El-Sayed, AA Ibrahim… - Organic Preparations …, 2021 - Taylor & Francis
1, 2, 4-Triazole moieties have been incorporated into a wide variety of therapeutically
interesting drug candidates including central nervous system stimulants, sedatives …