Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Multiblock copolymer synthesis via RAFT emulsion polymerization

GKK Clothier, TR Guimarães, SW Thompson… - Chemical Society …, 2023 - pubs.rsc.org
A multiblock copolymer is a polymer of a specific structure that consists of multiple covalently
linked segments, each comprising a different monomer type. The control of the monomer …

Emerging applications for living crystallization-driven self-assembly

L MacFarlane, C Zhao, J Cai, H Qiu, I Manners - Chemical Science, 2021 - pubs.rsc.org
The use of crystallization as a tool to control the self-assembly of polymeric and molecular
amphiphiles in solution is attracting growing attention for the creation of non-spherical …

Static and dynamic: evolving biomaterial mechanical properties to control cellular mechanotransduction

W Xie, X Wei, H Kang, H Jiang, Z Chu, Y Lin… - Advanced …, 2023 - Wiley Online Library
The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical,
biological, and chemical signals to embraced cells. Increasing evidence suggests that …

From precision polymers to complex materials and systems

JF Lutz, JM Lehn, EW Meijer… - Nature Reviews Materials, 2016 - nature.com
Complex chemical systems, such as living biological matter, are highly organized structures
based on discrete molecules in constant dynamic interactions. These natural materials can …

Supramolecular polymers in aqueous media

E Krieg, MMC Bastings, P Besenius… - Chemical …, 2016 - ACS Publications
This review discusses one-dimensional supramolecular polymers that form in aqueous
media. First, naturally occurring supramolecular polymers are described, in particular …

Fluoropolymer nanoparticles synthesized via reversible-deactivation radical polymerizations and their applications

Z Zhang, K Chen, B Ameduri, M Chen - Chemical Reviews, 2023 - ACS Publications
Fluorinated polymeric nanoparticles (FPNPs) combine unique properties of fluorocarbon
and polymeric nanoparticles, which has stimulated massive interest for decades. However …

50th Anniversary Perspective: Functional Nanoparticles from the Solution Self-Assembly of Block Copolymers

U Tritschler, S Pearce, J Gwyther, GR Whittell… - …, 2017 - ACS Publications
This Perspective outlines recent advances concerning the formation and potential uses of
block copolymer micelles, a class of soft-matter-based nanoparticles of growing importance …

Thermodynamics versus kinetics in nanosynthesis

Y Wang, J He, C Liu, WH Chong… - Angewandte Chemie …, 2015 - Wiley Online Library
One may discover a stone tool by chance but it takes more than luck to make a car or cell
phone. With the advance of nanoscience, the synthesis of increasingly sophisticated …

Polymerization-induced self-assembly: from soluble macromolecules to block copolymer nano-objects in one step

B Charleux, G Delaittre, J Rieger, F D'Agosto - Macromolecules, 2012 - ACS Publications
This Perspective describes the recent developments of polymerization-induced self-
assembly of amphiphilic block copolymers based on controlled/living free-radical …