Customizing cancer treatment at the nanoscale: a focus on anaplastic thyroid cancer therapy
J Wang, J Tan, B Wu, R Wu, Y Han, C Wang… - Journal of …, 2023 - Springer
Anaplastic thyroid cancer (ATC) is a rare but highly aggressive kind of thyroid cancer.
Various therapeutic methods have been considered for the treatment of ATC, but its …
Various therapeutic methods have been considered for the treatment of ATC, but its …
Structural insights into the mechanism of the sodium/iodide symporter
The sodium/iodide symporter (NIS) is the essential plasma membrane protein that mediates
active iodide (I−) transport into the thyroid gland, the first step in the biosynthesis of the …
active iodide (I−) transport into the thyroid gland, the first step in the biosynthesis of the …
Lipid‐Peptide‐mRNA Nanoparticles Augment Radioiodine Uptake in Anaplastic Thyroid Cancer
Q Li, L Zhang, J Lang, Z Tan, Q Feng, F Zhu… - Advanced …, 2023 - Wiley Online Library
Restoring sodium iodide symporter (NIS) expression and function remains a major
challenge for radioiodine therapy in anaplastic thyroid cancer (ATC). For more efficient …
challenge for radioiodine therapy in anaplastic thyroid cancer (ATC). For more efficient …
A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis
M Martín, CP Modenutti, ML Gil Rosas… - The Journal of …, 2021 - academic.oup.com
Context Iodide transport defect (ITD)(Online Mendelian Inheritance in Man No. 274400) is
an uncommon cause of dyshormonogenic congenital hypothyroidism due to loss-of-function …
an uncommon cause of dyshormonogenic congenital hypothyroidism due to loss-of-function …
Silent but Not Harmless: A Synonymous SLC5A5 Gene Variant Leading to Dyshormonogenic Congenital Hypothyroidism
Background Congenital iodide transport defect (ITD) is an uncommon cause of
dyshormonogenic congenital hypothyroidism characterized by the absence of active iodide …
dyshormonogenic congenital hypothyroidism characterized by the absence of active iodide …
The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane
M Martín, L Salleron, V Peyret, RC Geysels… - The FASEB …, 2021 - Wiley Online Library
The sodium/iodide symporter (NIS) expresses at the basolateral plasma membrane of the
thyroid follicular cell and mediates iodide accumulation required for normal thyroid …
thyroid follicular cell and mediates iodide accumulation required for normal thyroid …
Sirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder afrotheria
Sirenians of the superorder Afrotheria were the first mammals to transition from land to water
and are the only herbivorous marine mammals. Here, we generated a chromosome-level …
and are the only herbivorous marine mammals. Here, we generated a chromosome-level …
An intramolecular ionic interaction linking defective sodium/iodide symporter transport to the plasma membrane and dyshormonogenic congenital hypothyroidism
Background: The sodium/iodide symporter (NIS) mediates active iodide accumulation in the
thyroid follicular cell. Autosomal recessive iodide transport defect (ITD)-causing loss-of …
thyroid follicular cell. Autosomal recessive iodide transport defect (ITD)-causing loss-of …
Functional characterization of novel compound heterozygous missense SLC5A5 gene variants causing congenital dyshormonogenic hypothyroidism
Introduction The sodium/iodide symporter (NIS) mediates active iodide accumulation in the
thyroid follicular cell. Biallelic loss-of-function variants in the NIS-coding SLC5A5 gene …
thyroid follicular cell. Biallelic loss-of-function variants in the NIS-coding SLC5A5 gene …
Impact of the mutational landscape of the sodium/iodide symporter in congenital hypothyroidism
Background: Iodide transport defect is an uncommon cause of dyshormonogenic congenital
hypothyroidism due to homozygous or compound heterozygous pathogenic variants in the …
hypothyroidism due to homozygous or compound heterozygous pathogenic variants in the …