The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

2 Hypertension May 2018 acknowledged in VSMCs, whether it has any significance in
vascular pathophysiology linked to angiotensin II had not been studied. Recently, our group …

Mitochondria are essential for the maintenance of normal physiological function of tissue
cells. Mitochondria are subject to dynamic processes in order to establish a control system …

The heart is a functional syncytium controlled by a delicate and sophisticated balance
ensured by the tight coordination of its several cell subpopulations. Accordingly …

Mitochondria are central organelles in the homeostasis of the cardiovascular system via the
integration of several physiological processes, such as ATP generation via oxidative …

Cells respond to stress by activating a variety of defense signaling pathways, including cell
survival and cell death pathways. Although cell survival signaling helps the cell to recover …

Cardiac hypertrophy, a response of the heart to increased workload, is a major risk factor for
heart failure. Myostatin (MSTN) is an inhibitor of myogenesis, regulating the number and …

This study examined in vivo (1) skeletal muscle oxygenation and microvascular function, at
rest and during handgrip exercise, and (2) their association with macrovascular function and …

Hypertension remains an important modifiable risk factor for cardiovascular disease,
associated with increased morbidity and mortality. Deciphering the mechanisms involved in …

Mitochondria are one of the most important organelles in cardiomyocytes. Mitochondrial
homeostasis is necessary for the maintenance of normal heart function. Mitochondria …