T Regulatory cells (Tregs) can have both protective and pathological roles. They maintain
immune homeostasis and inhibit immune responses in various diseases, including cancer …

Advances in immunotherapy have led to durable and long‐term benefits in a subset of
patients across a number of solid tumor types. Understanding of the subsets of patients that …

Purpose Patients with squamous non–small-cell lung cancer (NSCLC) have poor prognosis
and limited treatment options. This randomized, double-blind, phase III study investigated …

Background The role of cancer cell FOXP3 in tumorigenesis is conflicting. We aimed to study
FOXP3 expression and regulation, function and clinical implication in human non-small cell …

As a major arm of the cellular immune response, CD4+ T cells are important in the control
and clearance of infections. Primarily described as helpers, CD4+ T cells play an integral …

Over the course of three decades of study, the deubiquitinase Herpesvirus associated
Ubiquitin-Specific Protease/Ubiquitin-Specific Protease 7 (HAUSP/USP7) has gradually …

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment paradigm for lung
cancer in recent years. These strategies consist of neutralizing antibodies against negative …

Although most researches and therapies have been focused on the tumor itself, it is
becoming clear that immune cells can not only suppress tumor development but support and …

An immunosuppressive microenvironment enriched with regulatory CD4+ T lymphocytes
(Tregs) facilitates the progression of lung adenocarcinoma (LUAD). This study aims to …

Abstract Foxp3+ T-regulatory (Treg) cells are known to suppress protective host immune
responses to a wide variety of solid tumors, but their therapeutic targeting is largely restricted …