In the realm of gene therapy, a pivotal moment arrived with Paul Berg's groundbreaking
identification of the first recombinant DNA in 1972. This achievement set the stage for future …

Polymers used for the delivery of nucleic acids (NAs) typically possess ionizable, cationic
moieties enabling their electrostatic interactions with negatively charged NAs and form …

Quinine is a promising building block for creating polymer carriers for intracellular nucleic
acid delivery. This is due to its ability to bind to genetic material through intercalation and …

Nucleic acid-based medicines and vaccines are becoming an important part of our
therapeutic toolbox. One key genetic medicine is antisense oligonucleotides (ASOs), which …

Antisense oligonucleotides (ASOs) are an important emerging therapeutic; however, they
struggle to enter cells without a delivery vehicle, such as a cationic polymer. To understand …

Herein, we examine the ASO-mediated gene silencing efficiency of pH-responsive micelles,
by incorporating 2-(diisopropylamino) ethyl methacrylate (DIP) into the micelle core and …

Broad size distributions and poor long‐term colloidal stability of microRNA‐carrying
nanoparticles, especially those formed by polyelectrolyte complexation, represent major …

Prostate cancer (PCa) is the most frequent cancer among men throughout the world. The
available conventional therapies such as androgen deprivation therapy and surgical …

Cationic polymers are known to efficiently deliver nucleic acids to target cells by
encapsulating the cargo into nanoparticles. However, the molecular organization of these …

The recent success of gene therapy during the COVID‐19 pandemic has underscored the
importance of effective and safe delivery systems. Complementing lipid‐based delivery …