Mechanistic target of rapamycin (mTOR) is a conserved serine/threonine kinase that plays a
critical role in the control of cellular growth and metabolism. Hyperactivation of mTOR …

DEP domain-containing mechanistic target of rapamycin (mTOR)-interacting protein
(DEPTOR) is an important modulator of mTOR, a kinase at the center of two important …

Single cell RNA sequencing studies identified novel neurodegeneration-associated
microglial (MGnD/DAM) subtypes activated around cerebral amyloid plaques. Micro-RNA …

Purpose: PARP inhibitors (PARPi) are primarily effective against BRCA1/2-mutated breast
and ovarian cancers, but resistance due to reversion of mutated BRCA1/2 and other …

Background & Aims Cumulating evidence underlines the crucial role of aberrant lipogenesis
in human hepatocellular carcinoma (HCC). Here, we investigated the oncogenic potential of …

Background mTOR inhibition of aromatase inhibitor (AI)-resistant breast cancer is currently
under evaluation in the clinic. Everolimus/RAD001 (Afinitor®) has had limited efficacy as a …

The consumption of cow's milk is a part of the basic nutritional habits of Western
industrialized countries. Recent epidemiological studies associate the intake of cow's milk …

Objective To investigate differential microRNAs' expression in heterogeneous bladder
cancer cells, as well as to investigate the mechanism of changes in invasive and …

Abstract microRNA‐155 (miR155) is pro‐atherogenic; however, its role in vascular
calcification is unknown. In this study, we aim to examine whether miR155 regulates …

Simple Summary Most breast cancers co-express estrogen receptor α (ERα) and
progesterone receptor (PgR). These cancers are sensitive to endocrine therapy and, in …