Stem cell therapy: a promising biological strategy for tendon–bone healing after anterior cruciate ligament reconstruction

ZC Hao, SZ Wang, XJ Zhang, J Lu - Cell proliferation, 2016 - Wiley Online Library
Tendon–bone healing after anterior cruciate ligament (ACL) reconstruction is a complex
process, impacting significantly on patients' prognosis. Natural tendon–bone healing usually …

Musculoskeletal tissue regeneration: the role of the stem cells

G Narayanan, M Bhattacharjee, LS Nair… - Regenerative …, 2017 - Springer
Ligament, cartilage, and meniscus injuries often have poor healing due to low vascularity
and low proliferative abilities of the resident cells. Drawbacks with conventional treatment …

Cryopreserved human adipose-derived stromal vascular fraction maintains fracture healing potential via angiogenesis and osteogenesis in an immunodeficient rat …

T Kamenaga, Y Kuroda, K Nagai, M Tsubosaka… - Stem Cell Research & …, 2021 - Springer
Background Novel therapeutic strategies for the healing of nonunion, which has serious
effects on the quality of life of patients, are needed. We evaluated the therapeutic effect of …

Increasing vascular response to injury improves tendon early healing outcome in aged rats

CN Riggin, SN Weiss, AB Rodriguez, H Raja… - Annals of biomedical …, 2022 - Springer
Tendon injuries positively correlate with patient age, as aging has significant effects on
tendon homeostatic maintenance and healing potential after injury. Vascularity is also …

The effect of remnant tissue preservation in anatomic double-bundle ACL reconstruction on knee stability and graft maturation

T Takahashi, M Kimura, K Hagiwara… - The Journal of Knee …, 2019 - thieme-connect.com
Several investigators have developed anterior cruciate ligament reconstructions (ACLR)
with remnant tissue preservation (RTP) and have reported better clinical outcomes …

Anterior cruciate ligament tibial insertion site is elliptical or triangular shaped in healthy young adults: high-resolution 3-T MRI analysis

Y Tashiro, GA Lucidi, T Gale, K Nagai, E Herbst… - Knee Surgery, Sports …, 2018 - Springer
Purpose To clarify the morphology of anterior cruciate ligament (ACL) tibial insertion site in
healthy young knees using high-resolution 3-T MRI. Methods Subjects were 50 ACL …

Age-dependent healing potential of anterior cruciate ligament remnant-derived cells

N Nakano, T Matsumoto, K Takayama… - … American Journal of …, 2015 - journals.sagepub.com
Background: The anterior cruciate ligament (ACL) does not heal spontaneously after injury,
and ACL patients of different ages respond differently to treatment. Although ACL-derived …

Influence of the injury-to-surgery interval on the healing potential of human anterior cruciate ligament–derived cells

T Inokuchi, T Matsumoto, K Takayama… - … American Journal of …, 2017 - journals.sagepub.com
Background: Vascular CD34+ cells in anterior cruciate ligament (ACL) tissue have the
potential for high proliferation and multilineage differentiation that can accelerate tendon …

Anterior cruciate ligament remnant tissue harvested within 3-months after injury predicts higher healing potential

S Zhang, T Matsumoto, A Uefuji, T Matsushita… - BMC Musculoskeletal …, 2015 - Springer
Background No study has examined the possible factors associated with different
characteristics of stem-like cells derived from anterior cruciate ligament (ACL) remnants. And …

Strategies to promote tendon-bone healing after anterior cruciate ligament reconstruction: Present and future

B Tian, M Zhang, X Kang - Frontiers in Bioengineering and …, 2023 - frontiersin.org
At present, anterior cruciate ligament (ACL) reconstruction still has a high failure rate.
Tendon graft and bone tunnel surface angiogenesis and bony ingrowth are the main …