Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

The obesity epidemic is a global issue and shows no signs of abating, while the cause of
this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally …

The “fetal” or “early” origins of adult disease hypothesis was originally put forward by David
Barker and colleagues and stated that environmental factors, particularly nutrition, act in …

Numerous clinical studies associate an adverse prenatal environment with the development
of cardio-metabolic disorders and neuroendocrine dysfunction, as well as an increased risk …

Epidemiological evidence suggests that an adverse prenatal environment
permanently'programs' physiology and increases the risk of cardiovascular, metabolic …

Life-history trade-offs between components of fitness arise because reproduction entails
both gains and costs. Costs of reproduction can be divided into ecological and physiological …

Epidemiological evidence suggests that low birth weight is associated with an increased risk
of cardiovascular, metabolic and neuroendocrine disorders in adult life. Glucocorticoid …

Environmental effects on the materno–foetal interaction determine birth outcomes that
predict health over the lifespan. Thus, maternal undernutrition or stress associate with low …

Epidemiological evidence suggests that an adverse fetal environment permanently
programs physiology, leading to increased risks of cardiovascular, metabolic, and …

Converging lines of evidence from epidemiological studies and animal models now indicate
that the origins of obesity and related metabolic disorders lie not only in the interaction …