Clinical trials of stem cell therapy for cerebral ischemic stroke

M Kawabori, H Shichinohe, S Kuroda… - International Journal of …, 2020 - mdpi.com
Despite recent developments in innovative treatment strategies, stroke remains one of the
leading causes of death and disability worldwide. Stem cell therapy is currently attracting …

Stem cells in human neurodegenerative disorders—time for clinical translation?

O Lindvall, Z Kokaia - The Journal of clinical investigation, 2010 - Am Soc Clin Investig
Stem cell–based approaches have received much hype as potential treatments for
neurodegenerative disorders. Indeed, transplantation of stem cells or their derivatives in …

Human neural stem cell extracellular vesicles improve recovery in a porcine model of ischemic stroke

RL Webb, EE Kaiser, BJ Jurgielewicz, S Spellicy… - Stroke, 2018 - Am Heart Assoc
Background and Purpose—Recent work from our group suggests that human neural stem
cell–derived extracellular vesicle (NSC EV) treatment improves both tissue and …

Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments

VC Henderson, J Kimmelman, D Fergusson… - PLoS …, 2013 - journals.plos.org
Background The vast majority of medical interventions introduced into clinical development
prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed …

RIGOR guidelines: escalating STAIR and STEPS for effective translational research

PA Lapchak, JH Zhang… - Translational stroke …, 2013 - Springer
Stroke continues to be a serious and significant health problem in the USA and worldwide.
This article will emphasize the need for good laboratory practices, transparent scientific …

Stem cell transplantation therapy and neurological disorders: current status and future perspectives

MM Rahman, MR Islam, MT Islam, M Harun-Or-Rashid… - Biology, 2022 - mdpi.com
Simple Summary This review highlights the scope of available treatment options for
neurological diseases, especially stem cell transplantation therapy, which provides new …

Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy

Y Ikegame, K Yamashita, SI Hayashi, H Mizuno… - …, 2011 - Taylor & Francis
Background aims. Transplantation of mesenchymal stromal cells (MSC) derived from bone
marrow (BM) or adipose tissue is expected to become a cell therapy for stroke. The present …

Effects of intravenous administration of allogenic bone marrow-and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in …

M Gutiérrez-Fernández, B Rodríguez-Frutos… - Stem cell research & …, 2013 - Springer
Introduction Stem cell therapy can promote good recovery from stroke. Several studies have
demonstrated that mesenchymal stem cells (MSC) are safe and effective. However, more …

Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke

L Wei, ZZ Wei, MQ Jiang, O Mohamad, SP Yu - Progress in neurobiology, 2017 - Elsevier
One of the exciting advances in modern medicine and life science is cell-based
neurovascular regeneration of damaged brain tissues and repair of neuronal structures. The …

The dark side of the force–constraints and complications of cell therapies for stroke

J Boltze, A Arnold, P Walczak, J Jolkkonen… - Frontiers in …, 2015 - frontiersin.org
Cell therapies are increasingly recognized as a promising option to augment the limited
therapeutic arsenal available to fight ischemic stroke. During the last two decades …