Context-specific regulation of extracellular vesicle biogenesis and cargo selection

AC Dixson, TR Dawson, D Di Vizio… - … Reviews Molecular Cell …, 2023 - nature.com
To coordinate, adapt and respond to biological signals, cells convey specific messages to
other cells. An important aspect of cell–cell communication involves secretion of molecules …

[HTML][HTML] Mechanisms of temozolomide resistance in glioblastoma-a comprehensive review

N Singh, A Miner, L Hennis, S Mittal - Cancer drug resistance, 2021 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an
exceedingly low median overall survival of only 15 months. Current standard-of-care for …

The p53 network: cellular and systemic DNA damage responses in cancer and aging

PL Vaddavalli, B Schumacher - Trends in Genetics, 2022 - cell.com
The tumor protein TP53 gene, encoding the cellular tumor antigen p53, is the single most
frequently mutated gene in human cancers. p53 plays a central role in responding to DNA …

[HTML][HTML] Wireless electrical–molecular quantum signalling for cancer cell apoptosis

A Jain, J Gosling, S Liu, H Wang, EM Stone… - Nature …, 2024 - nature.com
Quantum biological tunnelling for electron transfer is involved in controlling essential
functions for life such as cellular respiration and homoeostasis. Understanding and …

Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift

JE Park, B Dutta, SW Tse, N Gupta, CF Tan, JK Low… - Oncogene, 2019 - nature.com
Developing tumors rapidly outgrow their oxygen supply and are subject to hypoxia, which
stimulates hypersecretion of tumor-derived exosomes that promote angiogenesis …

[HTML][HTML] Role of hypoxia-induced exosomes in tumor biology

C Shao, F Yang, S Miao, W Liu, C Wang, Y Shu… - Molecular Cancer, 2018 - Springer
Purpose Hypoxia is a major regulator of angiogenesis and always influences the release of
exosomes in various types of tumors. The present review aimed to assess the role of …

[HTML][HTML] Hypoxia induced changes of exosome cargo and subsequent biological effects

H Jiang, H Zhao, M Zhang, Y He, X Li, Y Xu… - Frontiers in …, 2022 - frontiersin.org
Exosomes are small extracellular vesicles that are secreted by almost all types of cells and
exist in almost all extracellular spaces. As an important mediator of intercellular …

[HTML][HTML] Drug resistance in glioblastoma: the two faces of oxidative stress

C Olivier, L Oliver, L Lalier, FM Vallette - Frontiers in molecular …, 2021 - frontiersin.org
Glioblastomas (GBM) are the most common primary brain tumor with a median survival of 15
months. A population of cells with stem cell properties (glioblastoma stem cells, GSCs) …

[HTML][HTML] Small extracellular vesicles in cancer

K Abhange, A Makler, Y Wen, N Ramnauth, W Mao… - Bioactive Materials, 2021 - Elsevier
Extracellular vesicles (EV) are lipid-bilayer enclosed vesicles in submicron size that are
released from cells. A variety of molecules, including proteins, DNA fragments, RNAs, lipids …

[HTML][HTML] Molecular mechanisms of breast cancer metastasis to the lung: clinical and experimental perspectives

B Medeiros, AL Allan - International journal of molecular sciences, 2019 - mdpi.com
Breast cancer is the most commonly diagnosed cancer in women worldwide, and> 90% of
breast cancer-related deaths are associated with metastasis. Breast cancer spreads …