Frequent mutations in natural killer/T cell lymphoma
Y Zhang, C Li, W Xue, M Zhang, Z Li - Cellular Physiology and …, 2018 - karger.com
Extranodal natural killer (NK)/T cell lymphoma (ENKTL-NT or NKTCL), with its aggressive
nature and poor prognosis, has been widely studied to discover more effective treatment …
nature and poor prognosis, has been widely studied to discover more effective treatment …
Precancer atlas to drive precision prevention trials
A Spira, MB Yurgelun, L Alexandrov, A Rao, R Bejar… - Cancer research, 2017 - AACR
Cancer development is a complex process driven by inherited and acquired molecular and
cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality …
cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality …
Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming
Somatic inactivating mutations of ARID1A, a SWI/SNF chromatin remodeling gene, are
prevalent in human endometrium-related malignancies. To elucidate the mechanisms …
prevalent in human endometrium-related malignancies. To elucidate the mechanisms …
Dormant origins as a built-in safeguard in eukaryotic DNA replication against genome instability and disease development
N Shima, KD Pederson - DNA repair, 2017 - Elsevier
DNA replication is a prerequisite for cell proliferation, yet it can be increasingly challenging
for a eukaryotic cell to faithfully duplicate its genome as its size and complexity expands …
for a eukaryotic cell to faithfully duplicate its genome as its size and complexity expands …
Loss of ARID1A activates mTOR signaling and SOX9 in gastric adenocarcinoma—rationale for targeting ARID1A deficiency
Background Gastric adenocarcinoma (GAC) is a lethal disease with limited therapeutic
options. Genetic alterations in chromatin remodelling gene AT-rich interactive domain 1A …
options. Genetic alterations in chromatin remodelling gene AT-rich interactive domain 1A …
[HTML][HTML] Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancer
J Zou, W Qin, L Yang, L Wang, Y Wang… - American journal of …, 2020 - ncbi.nlm.nih.gov
Abstract The AT-rich Interactive Domain 1A (ARID1A) is one of the most frequently mutated
genes in gastric cancer. Here, we found that genetic variants in noncoding regions of …
genes in gastric cancer. Here, we found that genetic variants in noncoding regions of …
ARID1A suppresses malignant transformation of human pancreatic cells via mediating senescence-associated miR-503/CDKN2A regulatory axis
Z Li, S Zhu, X Chen, J Zhu, Q Chen, Y Zhang… - Biochemical and …, 2017 - Elsevier
ARID1A as a subunit of SWI/SNF chromatin complexes is frequently mutated in human
pancreatic cancer, however its exact role in pancreatic tumorigenesis remain unclear. In this …
pancreatic cancer, however its exact role in pancreatic tumorigenesis remain unclear. In this …
A segregating human allele of SPO11 modeled in mice disrupts timing and amounts of meiotic recombination, causing oligospermia and a decreased ovarian reserve
TN Tran, JC Schimenti - Biology of Reproduction, 2019 - academic.oup.com
A major challenge in medical genetics is to characterize variants of unknown significance
(VUS). Doing so would help delineate underlying causes of disease and the design of …
(VUS). Doing so would help delineate underlying causes of disease and the design of …
Prognostic significance of EZH2 and ARID1A expression in urothelial carcinoma: an immunohistochemical study
Enhancer of zeste homolog 2 (EZH2) and AT-rich interactive domain 1A (ARID1A)
expression in urothelial carcinoma (UC) has not been well studied. ARID1A is a novel tumor …
expression in urothelial carcinoma (UC) has not been well studied. ARID1A is a novel tumor …
[PDF][PDF] Wsb1 and Ksr1 gene add-backs to Chaos3 mammary tumor cells to analyze their role
H Shah - 2019 - ecommons.cornell.edu
The RAS protein is crucial in signaling pathways that regulate cellular proliferation. Tumors
can form when this normal growth regulation breaks down due to defects in signaling …
can form when this normal growth regulation breaks down due to defects in signaling …