The intestine represents the largest compartment of the immune system. It is continually
exposed to antigens and immunomodulatory agents from the diet and the commensal …

The pathogenesis of inflammatory bowel disease (IBD) is multifactorial with data suggesting
the role of a disturbed interaction between the gut and the intestinal microbiota. A defective …

The gut mucosa is constantly challenged by a bombardment of foreign antigens and
environmental microorganisms. As such, the precise regulation of the intestinal barrier …

Background & Aims: Increased inflammatory cytokine levels and intestinal epithelial cell
apoptosis leading to disruption of epithelial integrity are major pathologic factors in …

Genome-wide association studies have linked polymorphisms in the autophagy gene
ATG16L1 with susceptibility to inflammatory bowel disease (IBD). However, the cell-type …

Every 4–5 days, intestinal epithelial cells (IEC) are terminated as they reach the end of their
life. This process ensures that the epithelium is comprised of the fittest cells that maintain an …

The intestinal epithelium has a strategic position as a protective physical barrier to luminal
microbiota and actively contributes to the mucosal immune system. This barrier is mainly …

Intestinal epithelial cells (IECs) not only have a critical function in the absorption of nutrients,
but also act as a physical barrier between our body and the outside world. Damage and …

In inflammatory bowel disease (IBD), experimental models have proven to be important tools
for detecting potential therapeutic agents and for investigating the mechanisms of …

Tumor necrosis factor-alpha (TNFα) antagonists have shown remarkable efficacy in a variety
of immune-mediated inflammatory diseases (IMIDs). Therapeutic scope and limitations of …