Marek's disease virus: from miasma to model

N Osterrieder, JP Kamil, D Schumacher… - Nature Reviews …, 2006 - nature.com
Marek's disease virus (MDV) is an oncogenic herpesvirus that causes various clinical
syndromes in its natural host, the chicken. MDV has long been of interest as a model …

Marek's disease vaccines: a solution for today but a worry for tomorrow?

IM Gimeno - Vaccine, 2008 - Elsevier
Marek's disease (MD) is a lymphoproliferative disease of chickens that, in the absence of
control measures, is capable of causing devastating losses in commercial poultry flocks. MD …

The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription

G Gaudray, F Gachon, J Basbous… - Journal of …, 2002 - Am Soc Microbiol
The RNA genome of the human T-cell leukemia virus type 1 (HTLV-1) codes for proteins
involved in infectivity, replication, and transformation. We report in this study the …

Pathogenesis of Marek's disease virus infection

BW Calnek - Marek's disease, 2001 - Springer
The term pathogenesis is most simply defined as the development of disease. Many
uncomplicated infectious diseases proceed in a direct fashion from infection to a specific …

The genome of a very virulent Marek's disease virus

ER Tulman, CL Afonso, Z Lu, L Zsak, DL Rock… - Journal of …, 2000 - Am Soc Microbiol
Here we present the first complete genomic sequence, with analysis, of a very virulent strain
of Marek's disease virus serotype 1 (MDV1), Md5. The genome is 177,874 bp and is …

Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication

B Lupiani, LF Lee, X Cui, I Gimeno… - Proceedings of the …, 2004 - National Acad Sciences
Marek's disease virus (MDV) causes an acute lymphoproliferative disease in chickens,
resulting in T cell lymphomas in visceral organs and peripheral nerves. Earlier studies have …

Evolution of Marek's disease–a paradigm for incessant race between the pathogen and the host

V Nair - The Veterinary Journal, 2005 - Elsevier
Marek's disease (MD) is a highly contagious lymphoproliferative disease of poultry caused
by the oncogenic herpesvirus designated Marek's disease virus (MDV). MD has a worldwide …

Differential cytokine responses following Marek's disease virus infection of chickens differing in resistance to Marek's disease

P Kaiser, G Underwood, F Davison - Journal of virology, 2003 - Am Soc Microbiol
The production of cytokine mRNAs, in addition to viral DNA, was quantified by real-time
quantitative reverse transcription-PCR (RT-PCR)(cytokines) or PCR (virus) in splenocytes …

Marek's Disease Virus Encodes MicroRNAs That Map to meq and the Latency-Associated Transcript

J Burnside, E Bernberg, A Anderson, C Lu… - Journal of …, 2006 - Am Soc Microbiol
MicroRNAs (miRNAs) are a class of small (∼ 22-nucleotide) regulatory molecules that block
translation or induce degradation of target mRNAs. These have been identified in a wide …

The complete unique long sequence and the overall genomic organization of the GA strain of Marek's disease virus

LF Lee, P Wu, D Sui, D Ren, J Kamil… - Proceedings of the …, 2000 - National Acad Sciences
We have determined the DNA sequence of the unique long (UL) region and the repeat long
(RL) region in the genome of serotype 1 GA strain of Marek's disease virus (MDV), a …