[HTML][HTML] Clearance dysfunction of trans-barrier transport and lymphatic drainage in cerebral small vessel disease: review and prospect

H Zhu, S Li, Y Wang, B Song, Y Gao, Y Xu, Y Li - Neurobiology of Disease, 2023 - Elsevier
Cerebral small vessel disease (CSVD) causes 20%–25% of stroke and contributes to 45%
of dementia cases worldwide. However, since its early symptoms are inconclusive in …

Low-density lipoprotein receptor-related protein-1 (LRP1) in the glial lineage modulates neuronal excitability

A Faissner - Frontiers in Network Physiology, 2023 - frontiersin.org
The low-density lipoprotein related protein receptor 1 (LRP1), also known as CD91 or α-
Macroglobulin-receptor, is a transmembrane receptor that interacts with more than 40 known …

Repetitive head trauma and apoE4 induce chronic cerebrovascular alterations that impair tau elimination from the brain

M Eisenbaum, A Pearson, C Ortiz, M Koprivica… - Experimental …, 2024 - Elsevier
Repetitive mild traumatic brain injuries (r-mTBI) sustained in the military or contact sports
have been associated with the accumulation of extracellular tau in the brain, which may …

APOE from patient-derived astrocytic extracellular vesicles alleviates neuromyelitis optica spectrum disorder in a mouse model

S Jiang, X Li, Y Li, Z Chang, M Yuan, Y Zhang… - Science Translational …, 2024 - science.org
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy of the
central nervous system, mediated by antibodies against aquaporin-4 water channel protein …

[HTML][HTML] The guardian of intracranial vessels: Why the pericyte?

K Cen, YF Huang, Y Xie, YM Liu - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Intracranial atherosclerotic stenosis (ICAS) is a pathological condition characterized by
progressive narrowing or complete blockage of intracranial blood vessels caused by plaque …

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

CM Kloske, ME Belloy, EE Blue, GR Bowman… - Alzheimer's & … - Wiley Online Library
INTRODUCTION The apolipoprotein E gene (APOE) is an established central player in the
pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse …