Macrophages in heterotopic ossification: from mechanisms to therapy
Y Huang, X Wang, D Zhou, W Zhou, F Dai… - NPJ Regenerative …, 2021 - nature.com
Heterotopic ossification (HO) is the formation of extraskeletal bone in non-osseous tissues. It
is caused by an injury that stimulates abnormal tissue healing and regeneration, and …
is caused by an injury that stimulates abnormal tissue healing and regeneration, and …
Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and disease
The characterization of fibro/adipogenic progenitor cells (FAPs) in the skeletal muscle has
contributed to modify the monocentric view of muscle regeneration beyond muscle satellite …
contributed to modify the monocentric view of muscle regeneration beyond muscle satellite …
Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after …
J Zhang, YW Xiong, LL Tan, XM Zheng… - Journal of Hazardous …, 2023 - Elsevier
Little is currently known about the effect and mechanism of combined paternal
environmental cadmium (Cd) and high-fat diet (HFD) on offspring cognitive ability. Here …
environmental cadmium (Cd) and high-fat diet (HFD) on offspring cognitive ability. Here …
C5a-C5aR1 induces endoplasmic reticulum stress to accelerate vascular calcification via PERK-eIF2α-ATF4-CREB3L1 pathway
A Liu, Z Chen, X Li, C Xie, Y Chen, X Su… - Cardiovascular …, 2023 - academic.oup.com
Aims Vascular calcification (VC) predicts the morbidity and mortality in cardiovascular
diseases. Vascular smooth muscle cells (VSMCs) osteogenic transdifferentiation is the …
diseases. Vascular smooth muscle cells (VSMCs) osteogenic transdifferentiation is the …
Novel cardiovascular protective effects of RhoA signaling and its therapeutic implications
JEC Soh, A Shimizu, A Sato, H Ogita - Biochemical Pharmacology, 2023 - Elsevier
Ras homolog gene family member A (RhoA) belongs to the Rho GTPase superfamily, which
was first studied in cancers as one of the essential regulators controlling cellular function …
was first studied in cancers as one of the essential regulators controlling cellular function …
[HTML][HTML] Ethyl caffeate inhibits macrophage polarization via SIRT1/NF-κB to attenuate traumatic heterotopic ossification in mice
H Wang, D Song, L Wei, L Huang, D Wei, Y Su… - Biomedicine & …, 2023 - Elsevier
Heterotopic ossification (HO) denotes the presence of mature bone tissue in soft tissues or
around joints. Inflammation is a key driver of traumatic HO, and macrophages play an …
around joints. Inflammation is a key driver of traumatic HO, and macrophages play an …
[HTML][HTML] Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle
L Liu, X Yue, Z Sun, WS Hambright, Q Feng… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
The aging of the immune system, or immunosenescence, was recently verified to have a
causal role in driving the aging of solid organs, while the senolytic elimination of senescent …
causal role in driving the aging of solid organs, while the senolytic elimination of senescent …
Selective ablation of Nfix in macrophages attenuates muscular dystrophy by inhibiting fibro‐adipogenic progenitor‐dependent fibrosis
M Saclier, G Angelini, C Bonfanti, G Mura… - The Journal of …, 2022 - Wiley Online Library
Muscular dystrophies are genetic diseases characterized by chronic inflammation and
fibrosis. Macrophages are immune cells that sustain muscle regeneration upon acute injury …
fibrosis. Macrophages are immune cells that sustain muscle regeneration upon acute injury …
The Role of MicroRNA in the Pathogenesis of Duchenne Muscular Dystrophy
K Kiełbowski, E Bakinowska, G Procyk… - International Journal of …, 2024 - mdpi.com
Duchenne muscular dystrophy (DMD) is an X-linked progressive disorder associated with
muscle wasting and degeneration. The disease is caused by mutations in the gene that …
muscle wasting and degeneration. The disease is caused by mutations in the gene that …
The functional role of cellular senescence during vascular calcification in chronic kidney disease
YP Fang, Y Zhao, JY Huang, X Yang, Y Liu… - Frontiers in …, 2024 - frontiersin.org
Vascular calcification (VC) has emerged as a key predictor of cardiovascular events in
patients with chronic kidney disease (CKD). In recent years, an expanding body of research …
patients with chronic kidney disease (CKD). In recent years, an expanding body of research …