Protein–protein interactions (PPIs) govern all biological processes. Some small molecules
modulate PPIs through induced protein proximity. In particular, molecular glue degraders …

Small molecule degraders such as PROTACs (PROteolysis TArgeting Chimeras) have
emerged as new promising pharmacological modalities and the first PROTAC drug …

Programmable genome integration of large, diverse DNA cargo without DNA repair of
exposed DNA double-strand breaks remains an unsolved challenge in genome editing. We …

Identifying therapeutics to delay, and potentially reverse, age-related cognitive decline is
critical in light of the increased incidence of dementia-related disorders forecasted in the …

Reversing brain aging may be possible through systemic interventions such as exercise. We
found that administration of circulating blood factors in plasma from exercised aged mice …

Malignant tumors can evade destruction by the immune system by attracting immune-
suppressive regulatory T cells (Treg) cells. The IKZF2 (Helios) transcription factor plays a …

Using genetic resistance against bacterial blight (BB) caused by Xanthomonas oryzae
pathovar oryzae (Xoo) is a major objective in rice breeding programmes. Prime editing (PE) …

A new generation of heterobifunctional small molecules, termed proteolysis targeting
chimeras (PROTACs), targets proteins for degradation through recruitment to E3 ligases and …

Cancer cells have a characteristic metabolism, mostly caused by alterations in signal
transduction networks rather than mutations in metabolic enzymes. For metabolic drugs to …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the
causative agent of coronavirus disease 2019 (COVID-19). Although multiple mutations have …