Bone is a remarkable tissue that can respond to external stimuli. The importance of
mechanical forces on the mass and structural development of bone has long been accepted …

Mechanical environment has a crucial role in our organism at the different levels, ranging
from cells to tissues and our own organs. This regulatory role is especially relevant for …

In recent years, the mathematical and computational sciences have developed novel
methodologies and insights that can aid in designing advanced bioreactors, microfluidic …

Mechanical loads which are macroscopically acting onto bony organs, are known to
influence the activities of biological cells located in the pore spaces of bone, in particular so …

While bone tissue is a hierarchically organized material, mathematical formulations of bone
remodeling are often defined on the level of a millimeter-sized representative volume …

Biomedical research and clinical practice are struggling to cope with the growing complexity
that the progress of health care involves. The most challenging diseases, those with the …

Abstract Purpose of Review We re-evaluated clinical applications of image-to-FE models to
understand if clinical advantages are already evident, which proposals are promising, and …

Bone remodeling is a fundamental biological process that develops in bone tissue along its
whole lifetime. It refers to a continuous bone transformation with new bone formation and old …

The main motivation for “hierarchical biomechanics” is that the wide variability of mechanical
properties encountered at the macroscopic scale may be traced back to just a few …

Severe bone fractures are often treated by appending internal fixations. In unhealthy or
osteoporotic patients, post-implantation bone fractures can occur due to external impact (eg …