Mammalian cells take up extracellular material by a variety of different mechanisms that are
collectively termed endocytosis. Endocytic mechanisms serve many important cellular …

▪ Abstract Cysteine proteases have traditionally been viewed as lysosomal mediators of
terminal protein degradation. However, recent findings refute this limited view and suggest a …

Antigen-presenting cells contain a specialized late endocytic compartment, MIIC (major
histocompatibility complex [MHC] class II-enriched compartment), that harbors newly …

Association of major histocompatibility complex (MHC) class II molecules with peptides
occurs in a series of endocytic vacuoles, termed MHC class II-enriched compartments …

We have previously demonstrated that human peripheral blood low density mononuclear
cells cultured in granulocyte/macrophage colony-stimulating factor (GM-CSF) and …

DENDRITIC cells and thymic epithelial cells perform important immunoregulatory functions
by presenting antigens in the form of peptides bound to cell-surface major histocompatibility …

Rab5 and rab7 proteins belong to a superfamily of small molecular weight GTPases known
to be associated with early and late endosomes, respectively. The rab5 protein plays an …

▪ Abstract Class I and class II MHC molecules bind peptides during their biosynthetic
maturation and provide a continuously updated display of intracellular and environmental …

Despite controversies and debates, some fundamental properties of endosomes become
apparent when comparing results from in vivo and in vitro strategies used to study …

Abstract HUMAN leukocyte antigen (HLA)-DM is an unconventional major histocompatibility
complex (MHC) class II heterodimer that is important for B-cell-mediated antigen processing …