The aberrant behavior of cancer reflects upregulation of certain oncogenic signaling
pathways that promote proliferation, inhibit apoptosis, and enable the cancer to spread and …

Peroxisomal proliferator activated receptor γ (PPARγ) belongs to the family of nuclear
hormone receptors (NHRs), which directly regulate transcription of target genes. The …

Invasion and metastasis are the main causes of death in breast cancer patients. Increased
expression of matrix metalloproteinases (MMPs), especially gelatinases (MMP-2 and-9), has …

The peroxisome proliferators-activated receptor (PPAR) γ pathway is involved in cancer, but
it appears to have both tumor suppressor and oncogenic functions. In neuroblastoma cells …

The PPAR-gamma (PPAR-γ) activating thiazolidinedione (TZD) medications are a class of
drugs used to improve lipid and glucose metabolism in type-2 diabetes. In addition to their …

Breast cancer cell lines that express the nuclear peroxisome proliferator-activated receptor γ
(PPARγ) can be prompted to undergo growth arrest and differentiation when treated with …

We have previously demonstrated that peroxisome proliferator-activated receptor gamma
(PPARγ) is expressed and transcriptionally responsive to both synthetic and natural ligands …

It has been previously shown that PPARγ ligands induce apoptotic cell death in a variety of
cancer cells. Given the evidence that these ligands have a receptor-independent function …

Purpose: The peroxisome proliferator-activated receptor γ (PPARγ), a ligand-dependent
transcription factor belonging to the family of nuclear receptors, has been implicated in the …

Glioma survival is dismal, in part, due to an imbalance in antioxidant expression and activity.
Peroxisome proliferator-activated receptor (PPAR) agonists have antineoplastic properties …