Trends in the development of miRNA bioinformatics tools
L Chen, L Heikkinen, C Wang, Y Yang… - Briefings in …, 2019 - academic.oup.com
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression via
recognition of cognate sequences and interference of transcriptional, translational or …
recognition of cognate sequences and interference of transcriptional, translational or …
Updated review of advances in microRNAs and complex diseases: experimental results, databases, webservers and data fusion
MicroRNAs (miRNAs) are gene regulators involved in the pathogenesis of complex
diseases such as cancers, and thus serve as potential diagnostic markers and therapeutic …
diseases such as cancers, and thus serve as potential diagnostic markers and therapeutic …
Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs
Most metazoan microRNAs (miRNAs) target many genes for repression, but the nematode
lsy-6 miRNA is much less proficient. Here we show that the low proficiency of lsy-6 can be …
lsy-6 miRNA is much less proficient. Here we show that the low proficiency of lsy-6 can be …
Most mammalian mRNAs are conserved targets of microRNAs
RC Friedman, KKH Farh, CB Burge… - Genome research, 2009 - genome.cshlp.org
MicroRNAs (miRNAs) are small endogenous RNAs that pair to sites in mRNAs to direct post-
transcriptional repression. Many sites that match the miRNA seed (nucleotides 2–7) …
transcriptional repression. Many sites that match the miRNA seed (nucleotides 2–7) …
Identifying miRNAs, targets and functions
Abstract microRNAs (miRNAs) are small endogenous non-coding RNAs that function as the
universal specificity factors in post-transcriptional gene silencing. Discovering miRNAs …
universal specificity factors in post-transcriptional gene silencing. Discovering miRNAs …
[HTML][HTML] MicroRNAs: target recognition and regulatory functions
DP Bartel - cell, 2009 - cell.com
MicroRNAs (miRNAs) are endogenous∼ 23 nt RNAs that play important gene-regulatory
roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their …
roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their …
[HTML][HTML] Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of
RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes …
RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes …
The impact of microRNAs on protein output
MicroRNAs are endogenous∼ 23-nucleotide RNAs that can pair to sites in the messenger
RNAs of protein-coding genes to downregulate the expression from these messages …
RNAs of protein-coding genes to downregulate the expression from these messages …
RNAhybrid: microRNA target prediction easy, fast and flexible
J Krüger, M Rehmsmeier - Nucleic acids research, 2006 - academic.oup.com
In the elucidation of the microRNA regulatory network, knowledge of potential targets is of
highest importance. Among existing target prediction methods, RNAhybrid [M. Rehmsmeier …
highest importance. Among existing target prediction methods, RNAhybrid [M. Rehmsmeier …
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR
S Lebedeva, M Jens, K Theil, B Schwanhäusser… - Molecular cell, 2011 - cell.com
Posttranscriptional gene regulation relies on hundreds of RNA binding proteins (RBPs) but
the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA …
the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA …