Vertebrate limb bud development: moving towards integrative analysis of organogenesis
The limb bud is of paradigmatic value to understanding vertebrate organogenesis. Recent
genetic analysis in mice has revealed the existence of a largely self-regulatory limb bud …
genetic analysis in mice has revealed the existence of a largely self-regulatory limb bud …
The origin of the tetrapod limb: from expeditions to enhancers
I Schneider, NH Shubin - Trends in genetics, 2013 - cell.com
More than three centuries ago natural philosophers, and later anatomists, recognized a
fundamental organization to the skeleton of tetrapod limbs. Composed of three segments …
fundamental organization to the skeleton of tetrapod limbs. Composed of three segments …
[HTML][HTML] An ancient dental gene set governs development and continuous regeneration of teeth in sharks
The evolution of oral teeth is considered a major contributor to the overall success of jawed
vertebrates. This is especially apparent in cartilaginous fishes including sharks and rays …
vertebrates. This is especially apparent in cartilaginous fishes including sharks and rays …
[HTML][HTML] The fin-to-limb transition as the re-organization of a Turing pattern
A Turing mechanism implemented by BMP, SOX9 and WNT has been proposed to control
mouse digit patterning. However, its generality and contribution to the morphological …
mouse digit patterning. However, its generality and contribution to the morphological …
Evolution of Hoxa11 regulation in vertebrates is linked to the pentadactyl state
Y Kherdjemil, RL Lalonde, R Sheth, A Dumouchel… - Nature, 2016 - nature.com
The fin-to-limb transition represents one of the major vertebrate morphological innovations
associated with the transition from aquatic to terrestrial life and is an attractive model for …
associated with the transition from aquatic to terrestrial life and is an attractive model for …
Spiny and soft-rayed fin domains in acanthomorph fish are established through a BMP-gremlin-shh signaling network
With over 18,000 species, the Acanthomorpha, or spiny-rayed fishes, form the largest and
arguably most diverse radiation of vertebrates. One of the key novelties that contributed to …
arguably most diverse radiation of vertebrates. One of the key novelties that contributed to …
[HTML][HTML] Nipbl and mediator cooperatively regulate gene expression to control limb development
A Muto, S Ikeda, ME Lopez-Burks, Y Kikuchi… - PLoS …, 2014 - journals.plos.org
Haploinsufficiency for Nipbl, a cohesin loading protein, causes Cornelia de Lange
Syndrome (CdLS), the most common “cohesinopathy”. It has been proposed that the effects …
Syndrome (CdLS), the most common “cohesinopathy”. It has been proposed that the effects …
Mechanism of pectoral fin outgrowth in zebrafish development
Fins and limbs, which are considered to be homologous paired vertebrate appendages,
have obvious morphological differences that arise during development. One major …
have obvious morphological differences that arise during development. One major …
Sarcopterygian fin ontogeny elucidates the origin of hands with digits
How the hand and digits originated from fish fins during the Devonian fin-to-limb transition
remains unsolved. Controversy in this conundrum stems from the scarcity of ontogenetic …
remains unsolved. Controversy in this conundrum stems from the scarcity of ontogenetic …
The making of differences between fins and limbs
Abstract 'Evo‐devo', an interdisciplinary field based on developmental biology, includes
studies on the evolutionary processes leading to organ morphologies and functions. One …
studies on the evolutionary processes leading to organ morphologies and functions. One …