Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory
impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high …

The matrix metalloproteinases (MMPs), a family of 25 secreted and cell surface-bound
neutral proteinases, process a large array of extracellular and cell surface proteins under …

Tuberculosis (TB), a chronic infectious disease of global importance, is facing the
emergence of drug-resistant strains with few new drugs to treat the infection. Pulmonary …

Background It is unknown whether lesions in human TB are hypoxic or whether this
influences disease pathology. Human TB is characterised by extensive lung destruction …

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that have a number of
important physiological roles including remodelling of the extracellular matrix, facilitating cell …

Most individuals infected with Mycobacterium tuberculosis develop a latent infection, which
does not progress to active tuberculosis (TB). This occurs, in part, because infected …

Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB), most human hosts are able to contain the infection and avoid progression to active TB …

Treatment of tuberculosis (TB) remains challenging, with lengthy treatment durations and
complex drug regimens that are toxic and difficult to administer. Similar to the vast majority of …

Heightened morbidity and mortality in pulmonary tuberculosis (TB) are consequences of
complex disease processes triggered by the causative agent, Mycobacterium tuberculosis …