Transition Metal Complexes as Antimalarial Agents: A Review
In antimalarial drug development research, overcoming drug resistance has been a major
challenge for researchers. Nowadays, several drugs like chloroquine, mefloquine …
challenge for researchers. Nowadays, several drugs like chloroquine, mefloquine …
Computational multi‐target approach to target essential enzymes of Leishmania donovani using comparative molecular dynamic simulations and MMPBSA analysis
D Saha, A Nath Jha - Phytochemical Analysis, 2023 - Wiley Online Library
Introduction Visceral leishmaniasis (VL) is caused by Leishmania donovani. The purine and
pyrimidine pathways are essential for L. donovani. Simultaneously inhibiting multiple targets …
pyrimidine pathways are essential for L. donovani. Simultaneously inhibiting multiple targets …
Deciphering the role of protein phosphatases in apicomplexa: the future of innovative therapeutics?
A Fréville, B Gnangnon, AS Khelifa, M Gissot, J Khalife… - Microorganisms, 2022 - mdpi.com
Parasites belonging to the Apicomplexa phylum still represent a major public health and
world-wide socioeconomic burden that is greatly amplified by the spread of resistances …
world-wide socioeconomic burden that is greatly amplified by the spread of resistances …
An in silico quest for next-generation antimalarial drugs by targeting Plasmodium falciparum hexose transporter protein: a multi-pronged approach
A Altharawi, Y Riadi… - Journal of Biomolecular …, 2023 - Taylor & Francis
The emergence of artemisinin resistance by malaria parasites is a major challenge in the
fight against malaria, thus posing serious threat to the public health across the world. To …
fight against malaria, thus posing serious threat to the public health across the world. To …
Target-based virtual screening of natural compounds identifies a potent antimalarial with selective falcipain-2 inhibitory activity
A Uddin, S Gupta, T Mohammad, D Shahi… - Frontiers in …, 2022 - frontiersin.org
We employed a comprehensive approach of target-based virtual high-throughput screening
to find potential hits from the ZINC database of natural compounds against cysteine …
to find potential hits from the ZINC database of natural compounds against cysteine …
Comparative Proteomics and Genome-Wide Druggability Analyses Prioritized Promising Therapeutic Targets against Drug-Resistant Leishmania tropica
Leishmania tropica is a tropical parasite causing cutaneous leishmaniasis (CL) in humans.
Leishmaniasis is a serious public health threat, affecting an estimated 350 million people in …
Leishmaniasis is a serious public health threat, affecting an estimated 350 million people in …
Core-genome-mediated promising alternative drug and multi-epitope vaccine targets prioritization against infectious Clostridium difficile
Prevention of Clostridium difficile infection is challenging worldwide owing to its high
morbidity and mortality rates. C. difficile is currently being classified as an urgent threat by …
morbidity and mortality rates. C. difficile is currently being classified as an urgent threat by …
In silico and in vivo evaluations of multistage antiplasmodial potency and toxicity profiling of n-Hexadecanoic acid derived from Vernonia amygdalina
FID Afolayan, RA Odeyemi, RA Salaam - Frontiers in Pharmacology, 2024 - frontiersin.org
Background Despite the widely reported potentials of n-Hexadecanoic acid (HA) as a
bioactive, its multi-stage antiplasmodial activity and toxicity profiles remain largely unknown …
bioactive, its multi-stage antiplasmodial activity and toxicity profiles remain largely unknown …
Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle
E Schwarzer, O Skorokhod - International Journal of Molecular Sciences, 2024 - mdpi.com
Post-translational modifications (PTMs) are essential for regulating protein functions,
influencing various fundamental processes in eukaryotes. These include, but are not limited …
influencing various fundamental processes in eukaryotes. These include, but are not limited …
Molecular modelling, cytotoxicity & biological investigation of novel fluorinated diphenylamine chalcone derivatives
A Shah, K Desai, A Bhanusali, N Malek, N Naik… - Journal of Molecular …, 2024 - Elsevier
Abstract A unique series of 1-(3-(3, 4-difluorophenyl) amino) phenyl) ethan-1-one linked
fluorinated diphenylamine chalcones (A1-A7) were synthesized and characterized by NMR …
fluorinated diphenylamine chalcones (A1-A7) were synthesized and characterized by NMR …