In antimalarial drug development research, overcoming drug resistance has been a major
challenge for researchers. Nowadays, several drugs like chloroquine, mefloquine …

Introduction Visceral leishmaniasis (VL) is caused by Leishmania donovani. The purine and
pyrimidine pathways are essential for L. donovani. Simultaneously inhibiting multiple targets …

Parasites belonging to the Apicomplexa phylum still represent a major public health and
world-wide socioeconomic burden that is greatly amplified by the spread of resistances …

The emergence of artemisinin resistance by malaria parasites is a major challenge in the
fight against malaria, thus posing serious threat to the public health across the world. To …

We employed a comprehensive approach of target-based virtual high-throughput screening
to find potential hits from the ZINC database of natural compounds against cysteine …

Leishmania tropica is a tropical parasite causing cutaneous leishmaniasis (CL) in humans.
Leishmaniasis is a serious public health threat, affecting an estimated 350 million people in …

Prevention of Clostridium difficile infection is challenging worldwide owing to its high
morbidity and mortality rates. C. difficile is currently being classified as an urgent threat by …

Background Despite the widely reported potentials of n-Hexadecanoic acid (HA) as a
bioactive, its multi-stage antiplasmodial activity and toxicity profiles remain largely unknown …

Post-translational modifications (PTMs) are essential for regulating protein functions,
influencing various fundamental processes in eukaryotes. These include, but are not limited …

Abstract A unique series of 1-(3-(3, 4-difluorophenyl) amino) phenyl) ethan-1-one linked
fluorinated diphenylamine chalcones (A1-A7) were synthesized and characterized by NMR …